Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa)

Michael E White, Douglas W. Leaman, Timothy G. Ramsay, Kimberly A. Kampman, Catherine W. Ernst, Jeanne M. Osborne

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

1. 1. Diabetes had no significant effect on IGFBP-3 message and serum levels however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05). 2. 2. The induction of diabetes in pigs significantly increased the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05). 3. 3. Both liver message and serum IGFBP-2 were reduced to control levels with insulin therapy. 4. 4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of IGFBP-3 expression.

Original languageEnglish (US)
Pages (from-to)341-347
Number of pages7
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume106
Issue number2
DOIs
StatePublished - Oct 1993

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