Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa)

Michael E White; Douglas W. Leaman; Timothy G. Ramsay; Kimberly A. Kampman; Catherine W. Ernst; Jeanne M. Osborne

doi:10.1016/0305-0491(93)90311-R

Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa)

Michael E White, Douglas W. Leaman, Timothy G. Ramsay, Kimberly A. Kampman, Catherine W. Ernst, Jeanne M. Osborne

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Abstract

1. 1. Diabetes had no significant effect on IGFBP-3 message and serum levels however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05). 2. 2. The induction of diabetes in pigs significantly increased the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05). 3. 3. Both liver message and serum IGFBP-2 were reduced to control levels with insulin therapy. 4. 4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of IGFBP-3 expression.

Original language	English (US)
Pages (from-to)	341-347
Number of pages	7
Journal	Comparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume	106
Issue number	2
DOIs	https://doi.org/10.1016/0305-0491(93)90311-R
State	Published - Oct 1993

Bibliographical note

Funding Information:
In biological fluids, IGFs are complexed to specific binding proteins which can modulate their biological action (Elgin et al., 1987; Clemmons et al., 1987; De Vroede et al., 1986; De Mellow and Baxter, 1988; Cornell et al., 1987; Gopinath et al., 1989; Walton et aL, 1989; Blum et al., 1989). Postnatally, the majority of the circulating IGF is bound to IGFBP-3 in the 150 kDa IGF binding complex (Baxter, 1991). Presently the cDNAs for six different IGFBPs (IGFBP-1 through 6) have been cloned and sequenced (Shimasaki et al., 1991a,b). Two of the predominant IGFBPs found in porcine serum are IGFBP-3 and -2 (Coleman et al., 1991). Circulating levels of these two IGFBPs have been shown to be differentially regulated by growth hormone and nutri- *Published as article No. 20,061 of the Scientific Journal Series of the Minnesota Agricultural Experiment station, Project No. 16-068. Supported in part by USDA Grant No. 87-37265-2598. tTo whom correspondence should be addressed at: Depart-ment of Animal Science, University of Minnesota, 137 Peters Hall, 1404 Gortner Ave., St. Paul, MN 55108, U.S.A.

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Copyright 2014 Elsevier B.V., All rights reserved.

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White, M. E., Leaman, D. W., Ramsay, T. G., Kampman, K. A., Ernst, C. W., & Osborne, J. M. (1993). Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa). Comparative Biochemistry and Physiology -- Part B: Biochemistry and, 106(2), 341-347. https://doi.org/10.1016/0305-0491(93)90311-R

Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa). / White, Michael E; Leaman, Douglas W.; Ramsay, Timothy G.; Kampman, Kimberly A.; Ernst, Catherine W.; Osborne, Jeanne M.

In: Comparative Biochemistry and Physiology -- Part B: Biochemistry and, Vol. 106, No. 2, 10.1993, p. 341-347.

Research output: Contribution to journal › Article › peer-review

White, ME, Leaman, DW, Ramsay, TG, Kampman, KA, Ernst, CW & Osborne, JM 1993, 'Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa)', Comparative Biochemistry and Physiology -- Part B: Biochemistry and, vol. 106, no. 2, pp. 341-347. https://doi.org/10.1016/0305-0491(93)90311-R

White, Michael E ; Leaman, Douglas W. ; Ramsay, Timothy G. ; Kampman, Kimberly A. ; Ernst, Catherine W. ; Osborne, Jeanne M. / Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa). In: Comparative Biochemistry and Physiology -- Part B: Biochemistry and. 1993 ; Vol. 106, No. 2. pp. 341-347.

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abstract = "1. 1. Diabetes had no significant effect on IGFBP-3 message and serum levels however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05). 2. 2. The induction of diabetes in pigs significantly increased the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05). 3. 3. Both liver message and serum IGFBP-2 were reduced to control levels with insulin therapy. 4. 4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of IGFBP-3 expression.",

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note = "Funding Information: In biological fluids, IGFs are complexed to specific binding proteins which can modulate their biological action (Elgin et al., 1987; Clemmons et al., 1987; De Vroede et al., 1986; De Mellow and Baxter, 1988; Cornell et al., 1987; Gopinath et al., 1989; Walton et aL, 1989; Blum et al., 1989). Postnatally, the majority of the circulating IGF is bound to IGFBP-3 in the 150 kDa IGF binding complex (Baxter, 1991). Presently the cDNAs for six different IGFBPs (IGFBP-1 through 6) have been cloned and sequenced (Shimasaki et al., 1991a,b). Two of the predominant IGFBPs found in porcine serum are IGFBP-3 and -2 (Coleman et al., 1991). Circulating levels of these two IGFBPs have been shown to be differentially regulated by growth hormone and nutri- *Published as article No. 20,061 of the Scientific Journal Series of the Minnesota Agricultural Experiment station, Project No. 16-068. Supported in part by USDA Grant No. 87-37265-2598. tTo whom correspondence should be addressed at: Depart-ment of Animal Science, University of Minnesota, 137 Peters Hall, 1404 Gortner Ave., St. Paul, MN 55108, U.S.A. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Leaman, Douglas W.

AU - Ramsay, Timothy G.

AU - Kampman, Kimberly A.

AU - Ernst, Catherine W.

AU - Osborne, Jeanne M.

N1 - Funding Information: In biological fluids, IGFs are complexed to specific binding proteins which can modulate their biological action (Elgin et al., 1987; Clemmons et al., 1987; De Vroede et al., 1986; De Mellow and Baxter, 1988; Cornell et al., 1987; Gopinath et al., 1989; Walton et aL, 1989; Blum et al., 1989). Postnatally, the majority of the circulating IGF is bound to IGFBP-3 in the 150 kDa IGF binding complex (Baxter, 1991). Presently the cDNAs for six different IGFBPs (IGFBP-1 through 6) have been cloned and sequenced (Shimasaki et al., 1991a,b). Two of the predominant IGFBPs found in porcine serum are IGFBP-3 and -2 (Coleman et al., 1991). Circulating levels of these two IGFBPs have been shown to be differentially regulated by growth hormone and nutri- *Published as article No. 20,061 of the Scientific Journal Series of the Minnesota Agricultural Experiment station, Project No. 16-068. Supported in part by USDA Grant No. 87-37265-2598. tTo whom correspondence should be addressed at: Depart-ment of Animal Science, University of Minnesota, 137 Peters Hall, 1404 Gortner Ave., St. Paul, MN 55108, U.S.A. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1993/10

Y1 - 1993/10

N2 - 1. 1. Diabetes had no significant effect on IGFBP-3 message and serum levels however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05). 2. 2. The induction of diabetes in pigs significantly increased the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05). 3. 3. Both liver message and serum IGFBP-2 were reduced to control levels with insulin therapy. 4. 4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of IGFBP-3 expression.

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Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa)

Abstract

Bibliographical note

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