Insulin like growth factor 1 receptor signal transduction to the nucleus

S. A. Rosenzweig; B. S. Oemar; N. M. Law; U. T. Shankavaram; B. S. Miller

Insulin like growth factor 1 receptor signal transduction to the nucleus

S. A. Rosenzweig
, B. S. Oemar
, N. M. Law
, U. T. Shankavaram
, B. S. Miller

Pediatric Endocrinology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided with a model system for pursuing the molecular mechanisms triggered by IGF-1 action.

Original language	English (US)
Pages (from-to)	159-168
Number of pages	10
Journal	Advances in experimental medicine and biology
Volume	343
State	Published - 1993

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title = "Insulin like growth factor 1 receptor signal transduction to the nucleus",

abstract = "The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided with a model system for pursuing the molecular mechanisms triggered by IGF-1 action.",

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year = "1993",

language = "English (US)",

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T1 - Insulin like growth factor 1 receptor signal transduction to the nucleus

AU - Rosenzweig, S. A.

AU - Oemar, B. S.

AU - Law, N. M.

AU - Shankavaram, U. T.

AU - Miller, B. S.

PY - 1993

Y1 - 1993

N2 - The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided with a model system for pursuing the molecular mechanisms triggered by IGF-1 action.

AB - The mechanism by which IGF-1Rs regulate the growth and maintenance of cells in normal and disease states provides an important setting for studies addressing signal transduction events at the nuclear level. With the identification of c-Jun/AP-1 as a nuclear target of IGF-1 action we are provided with a model system for pursuing the molecular mechanisms triggered by IGF-1 action.

UR - https://www.scopus.com/pages/publications/0027717812

UR - https://www.scopus.com/pages/publications/0027717812#tab=citedBy

M3 - Article

C2 - 8184736

AN - SCOPUS:0027717812

SN - 0065-2598

VL - 343

SP - 159

EP - 168

JO - Advances in experimental medicine and biology

JF - Advances in experimental medicine and biology

ER -

Insulin like growth factor 1 receptor signal transduction to the nucleus

Abstract

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