Instructing Memory in CD8+ Thymocytes

Katherine Maude Ashby, Kristin Ann Hogquist

Research output: Contribution to journalShort surveypeer-review


T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such ‘memory phenotype’ (MP) CD8+ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1.

Original languageEnglish (US)
Pages (from-to)556-558
Number of pages3
JournalTrends in Immunology
Issue number7
StatePublished - Jul 2020

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health grant AI39560 (to K.A.H.).

Publisher Copyright:
© 2020 Elsevier Ltd

Copyright 2020 Elsevier B.V., All rights reserved.


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