Instructing Memory in CD8+ Thymocytes

Katherine Maude Ashby; Kristin Ann Hogquist

doi:10.1016/j.it.2020.05.006

Instructing Memory in CD8⁺ Thymocytes

Katherine Maude Ashby, Kristin Ann Hogquist

Research output: Contribution to journal › Short survey › peer-review

Abstract

T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such ‘memory phenotype’ (MP) CD8⁺ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1.

Original language	English (US)
Pages (from-to)	556-558
Number of pages	3
Journal	Trends in Immunology
Volume	41
Issue number	7
DOIs	https://doi.org/10.1016/j.it.2020.05.006
State	Published - Jul 2020

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health grant AI39560 (to K.A.H.).

Publisher Copyright:
© 2020 Elsevier Ltd

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Publisher link

10.1016/j.it.2020.05.006

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title = "Instructing Memory in CD8+ Thymocytes",

abstract = "T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such {\textquoteleft}memory phenotype{\textquoteright} (MP) CD8+ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1.",

author = "Ashby, {Katherine Maude} and Hogquist, {Kristin Ann}",

note = "Funding Information: This work was supported by National Institutes of Health grant AI39560 (to K.A.H.). Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

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doi = "10.1016/j.it.2020.05.006",

language = "English (US)",

volume = "41",

pages = "556--558",

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AU - Ashby, Katherine Maude

AU - Hogquist, Kristin Ann

N1 - Funding Information: This work was supported by National Institutes of Health grant AI39560 (to K.A.H.). Publisher Copyright: © 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/7

Y1 - 2020/7

N2 - T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such ‘memory phenotype’ (MP) CD8+ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1.

AB - T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such ‘memory phenotype’ (MP) CD8+ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1.

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