INSPPIRE: Advances in the Understanding of Pediatric Pancreatitis

This is the summary of an April 2025 Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC) workshop highlighting the accomplishments of INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE)-2. INSPPIRE-2 goals and objectives have been to study the risk factors, natural history and outcomes of pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Structured patient and physician questionnaires have been used to collect information on demographics, clinical history, family and social history, and disease outcomes. Biosamples have been collected primarily for DNA isolation and analysis of key genes associated with pancreatitis, alongside ancillary studies aimed at elucidating disease pathophysiology and advancing the development of improved diagnostic and therapeutic strategies. Twenty-six sites have enrolled >1000 subjects into the INSPPIRE-2 database with available prospective data to evaluate disease progression, phenotypes, complications and outcomes. The available resources are outlined along with key discoveries offering readers topic specific information about INSPPIRE’s progress.