Insights into Langerhans cell function from Langerhans cell ablation models

Daniel H. Kaplan, Adrien Kissenpfennig, Björn E. Clausen

Research output: Contribution to journalShort surveypeer-review

121 Scopus citations

Abstract

Langerhans cells (LC) are the principal dendritic cell (DC) population in the epidermis of the skin. Owing to their prominent position at the environmental barrier, LC have long been considered to be prototypic sentinel DC. More recently, the precise role of LC in the initiation and control of cutaneous immune responses has become debatable. To elucidate their contribution to immune regulation in the skin, our laboratories have generated genetically modified mice in which LC can be followed in situ by expression of enhanced green fluorescent protein and can be either inducibly or constitutively depleted in vivo. This review highlights the similarities and differences between these mouse models, discusses the discovery and functional significance of Langerin+ dermal DC, and examines some recent data that help to shed light on LC function.

Original languageEnglish (US)
Pages (from-to)2369-2376
Number of pages8
JournalEuropean Journal of Immunology
Volume38
Issue number9
DOIs
StatePublished - Sep 2008

Keywords

  • Contact hypersensitivity
  • Dendritic cell
  • Langerhans cell
  • Langerin
  • Skin immunity

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