Insidious Transmission of a Stress-Related Neuroadaptation

Jennifer S. Steger, Benjamin B. Land, Julia C. Lemos, Charles Chavkin, Paul E.M. Phillips

Research output: Contribution to journalArticlepeer-review

Abstract

Stress is highly pervasive in humans, impacting motivated behaviors with an enormous toll on life quality. Many of the effects of stress are orchestrated by neuropeptides such as corticotropin-releasing factor (CRF). It has previously been shown that in stress-naïve male mice, CRF acts in the core of the nucleus accumbens (NAc) to produce appetitive effects and to increase dopamine release; yet in stress-exposed male mice, CRF loses its capacity to modulate NAc dopamine release and is aversive. In the current research, we tested whether this effect is comparable in females to males and whether the neuroadaptation is susceptible to social transmission. We found that, like in males, CRF increased dopamine release in stress-naïve but not stress-exposed female mice. Importantly, this persistent physiological change was not accompanied by overt behavioral changes that would be indicative of depression- or anxiety-like phenotype. Nonetheless, when these mice were housed for 7 days with stress-naïve conspecifics, the cage mates also exhibited a loss of dopamine potentiation by CRF. These data demonstrate the asymptomatic, yet pervasive transmission of stress-related neuroadaptations in the population.

Original languageEnglish (US)
Article number564054
JournalFrontiers in Behavioral Neuroscience
Volume14
DOIs
StatePublished - Oct 5 2020

Bibliographical note

Funding Information:
We thank Scott Ng-Evans and Lauren M. Burgeno for technical assistance and Michael R. Bruchas for feedback on the manuscript. Behavioral testing resources were provided by the Center on Human Development and Disability Mouse Behavior Lab at the University of Washington. Funding. This research was supported by National Institute of Health (NIH) grants T32 DA07278 and R01 DA051686 from National Institute on Drug Abuse (NIDA) and a National Institute of Mental Health (NIMH) Conte Center grant P50 MH106428.

Funding Information:
This research was supported by National Institute of Health (NIH) grants T32 DA07278 and R01 DA051686 from National Institute on Drug Abuse (NIDA) and a National Institute of Mental Health (NIMH) Conte Center grant P50 MH106428.

Publisher Copyright:
© Copyright © 2020 Steger, Land, Lemos, Chavkin and Phillips.

Keywords

  • CRF
  • dopamine
  • fast-scan cyclic voltammetry
  • nucleus accumbens
  • social stress
  • stress
  • stress transmission

PubMed: MeSH publication types

  • Journal Article

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