Innexin-3 forms connexin-like intercellular channels

Yosef Landesman, Thomas W. White, Todd A Starich, Jocelyn E. Shaw, Daniel A. Goodenough, David L. Paul

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Innexins comprise a large family of genes that are believed to encode invertebrate gap junction channel-forming proteins. However, only two Drosophila innexins have been directly tested for the ability to form intercellular channels and only one of those was active. Here we tested the ability of Caenorhabditis elegans family members INX-3 and EAT-5 to form intercellular channels between paired Xenopus oocytes. We show that expression of INX-3 but not EAT-5, induces electrical coupling between the oocyte pairs. In addition, analysis of INX-3 voltage and pH gating reveals a striking degree of conservation in the functional properties of connexin and innnexin channels. These data strongly support the idea that innexin genes encode intercellular channels.

Original languageEnglish (US)
Pages (from-to)2391-2396
Number of pages6
JournalJournal of cell science
Volume112
Issue number14
StatePublished - 1999

Keywords

  • Gap junction
  • Innexin
  • Intercellular channel
  • eat-5
  • inx-3

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