Innate Memory T cells

Research output: Chapter in Book/Report/Conference proceedingChapter

72 Scopus citations


Memory T cells are usually considered to be a feature of a successful immune response against a foreign antigen, and such cells can mediate potent immunity. However, in mice, alternative pathways have been described, through which naïve T cells can acquire the characteristics and functions of memory T cells without encountering specific foreign antigen or the typical signals required for conventional T cell differentiation. Such cells reflect a response to the internal rather the external environment, and hence such cells are called innate memory T cells. In this review, we describe how innate memory subsets were identified, the signals that induce their generation and their functional properties and potential role in the normal immune response. The existence of innate memory T cells in mice raises questions about whether parallel populations exist in humans, and we discuss the evidence for such populations during human T cell development and differentiation.

Original languageEnglish (US)
Title of host publicationAdvances in Immunology
PublisherAcademic Press Inc.
Number of pages41
StatePublished - 2015

Publication series

NameAdvances in Immunology
ISSN (Print)0065-2776
ISSN (Electronic)1557-8445

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.


  • CD8 T cells
  • Cytokines
  • Homeostasis
  • Immune memory
  • NKT cells


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