Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion

Yongsheng Pan, Yue Zhao, Rong Kuang, Hou Liu, Duo Sun, Tianjiao Mao, Kexin Jiang, Xinting Yang, Nobumoto Watanabe, Kevin H. Mayo, Quan Lin, Jiang Li

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


In stomatology, the promotion of alveolar bone regeneration while preventing the reduction of ridge absorption remains a challenge. In this work, we designed and prepared bio-mimetic polysaccharide hydrogels that are multi-functional in terms of being injectable, promote self-healing, degradable, porous structure, et al. After introducing nano-hydroxyapatite particles, the composite scaffold of hydrogel/hydroxyapatite (GH) stent was obtained. When GH material was injected into the mandibular incisors of rats following tooth extraction, the new bone area was enhanced more than 50%, while the alveolar ridge was promoted in excess of 60% after 4 weeks. What's more, the wound soft tissue was healed within 1 week. Overall, our results indicate that this optimized GH stent has the potential to both maintain dimensional alveolar ridge, as well as to promote soft tissue healing. Moreover, using the hydroxyapatite-containing hydrogel platform has the potential to promote bone and soft tissue regeneration.

Original languageEnglish (US)
Article number111158
JournalMaterials Science and Engineering C
StatePublished - Nov 2020

Bibliographical note

Funding Information:
This work was supported by Ministry of Science and Technology, China (No. 2016YFE0128500 ), Jilin Provincial Science and Technology Department (No. 20170204009YY ), National Natural Science Foundation of China (Grant No. 51861145311 ) and Open Project of State Key Laboratory of Superhard Materials (Jilin University 201802 ), Changchun Science and Technology Bureau (No. 17YJ001 ), and Jilin Province Development and Reform Commission (No. 2016C048-3 ).

Publisher Copyright:
© 2020 Elsevier B.V.


  • Alveolar ridge preservation
  • Injectable hydrogel
  • Nano-hydroxyapatite
  • Osteogenesis
  • Soft tissue healing


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