TY - JOUR
T1 - Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion
AU - Pan, Yongsheng
AU - Zhao, Yue
AU - Kuang, Rong
AU - Liu, Hou
AU - Sun, Duo
AU - Mao, Tianjiao
AU - Jiang, Kexin
AU - Yang, Xinting
AU - Watanabe, Nobumoto
AU - Mayo, Kevin H.
AU - Lin, Quan
AU - Li, Jiang
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/11
Y1 - 2020/11
N2 - In stomatology, the promotion of alveolar bone regeneration while preventing the reduction of ridge absorption remains a challenge. In this work, we designed and prepared bio-mimetic polysaccharide hydrogels that are multi-functional in terms of being injectable, promote self-healing, degradable, porous structure, et al. After introducing nano-hydroxyapatite particles, the composite scaffold of hydrogel/hydroxyapatite (GH) stent was obtained. When GH material was injected into the mandibular incisors of rats following tooth extraction, the new bone area was enhanced more than 50%, while the alveolar ridge was promoted in excess of 60% after 4 weeks. What's more, the wound soft tissue was healed within 1 week. Overall, our results indicate that this optimized GH stent has the potential to both maintain dimensional alveolar ridge, as well as to promote soft tissue healing. Moreover, using the hydroxyapatite-containing hydrogel platform has the potential to promote bone and soft tissue regeneration.
AB - In stomatology, the promotion of alveolar bone regeneration while preventing the reduction of ridge absorption remains a challenge. In this work, we designed and prepared bio-mimetic polysaccharide hydrogels that are multi-functional in terms of being injectable, promote self-healing, degradable, porous structure, et al. After introducing nano-hydroxyapatite particles, the composite scaffold of hydrogel/hydroxyapatite (GH) stent was obtained. When GH material was injected into the mandibular incisors of rats following tooth extraction, the new bone area was enhanced more than 50%, while the alveolar ridge was promoted in excess of 60% after 4 weeks. What's more, the wound soft tissue was healed within 1 week. Overall, our results indicate that this optimized GH stent has the potential to both maintain dimensional alveolar ridge, as well as to promote soft tissue healing. Moreover, using the hydroxyapatite-containing hydrogel platform has the potential to promote bone and soft tissue regeneration.
KW - Alveolar ridge preservation
KW - Injectable hydrogel
KW - Nano-hydroxyapatite
KW - Osteogenesis
KW - Soft tissue healing
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U2 - 10.1016/j.msec.2020.111158
DO - 10.1016/j.msec.2020.111158
M3 - Article
C2 - 32806272
AN - SCOPUS:85086731628
SN - 0928-4931
VL - 116
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 111158
ER -