Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion

Yongsheng Pan, Yue Zhao, Rong Kuang, Hou Liu, Duo Sun, Tianjiao Mao, Kexin Jiang, Xinting Yang, Nobumoto Watanabe, Kevin H. Mayo, Quan Lin, Jiang Li

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In stomatology, the promotion of alveolar bone regeneration while preventing the reduction of ridge absorption remains a challenge. In this work, we designed and prepared bio-mimetic polysaccharide hydrogels that are multi-functional in terms of being injectable, promote self-healing, degradable, porous structure, et al. After introducing nano-hydroxyapatite particles, the composite scaffold of hydrogel/hydroxyapatite (GH) stent was obtained. When GH material was injected into the mandibular incisors of rats following tooth extraction, the new bone area was enhanced more than 50%, while the alveolar ridge was promoted in excess of 60% after 4 weeks. What's more, the wound soft tissue was healed within 1 week. Overall, our results indicate that this optimized GH stent has the potential to both maintain dimensional alveolar ridge, as well as to promote soft tissue healing. Moreover, using the hydroxyapatite-containing hydrogel platform has the potential to promote bone and soft tissue regeneration.

Original languageEnglish (US)
Article number111158
JournalMaterials Science and Engineering C
Volume116
DOIs
StatePublished - Nov 2020

Keywords

  • Alveolar ridge preservation
  • Injectable hydrogel
  • Nano-hydroxyapatite
  • Osteogenesis
  • Soft tissue healing

PubMed: MeSH publication types

  • Journal Article

Fingerprint Dive into the research topics of 'Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion'. Together they form a unique fingerprint.

  • Cite this

    Pan, Y., Zhao, Y., Kuang, R., Liu, H., Sun, D., Mao, T., Jiang, K., Yang, X., Watanabe, N., Mayo, K. H., Lin, Q., & Li, J. (2020). Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion. Materials Science and Engineering C, 116, [111158]. https://doi.org/10.1016/j.msec.2020.111158