Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells

Debra J. Martin, Brian G. Van Ness

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

The splicing patterns and sequences of two processed kappa immunoglobulin germ line mRNAs are presented. A 1.1-kilobase (kb) mRNA appeared to be derived from splicing of the previously characterized 8.4-kb germ line transcript, while a 0.8-kb mRNA was the splice product of a second 4.7-kb germ line transcript that initiated 50 base pairs upstream of Jκ1. The interaction of the two kappa germ line promoters with nuclear binding factors is also examined. The potential role of these germ line transcripts in establishing the rearrangement potential of the locus is discussed.

Original languageEnglish (US)
Pages (from-to)1950-1958
Number of pages9
JournalMolecular and cellular biology
Volume10
Issue number5
DOIs
StatePublished - 1990

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