Initial recovery and rebound of type F intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin

Ryan P. Fagan; Karen P. Neil; Randy Sasich; Carolina Luquez; Hakam Asaad; Susan Maslanka; Wajahat Khalil

doi:10.1093/cid/cir550

Initial recovery and rebound of type F intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin

Ryan P. Fagan
, Karen P. Neil
, Randy Sasich
, Carolina Luquez
, Hakam Asaad
, Susan Maslanka
, Wajahat Khalil

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.

Original language	English (US)
Pages (from-to)	e125-e128
Journal	Clinical Infectious Diseases
Volume	53
Issue number	9
DOIs	https://doi.org/10.1093/cid/cir550
State	Published - Nov 1 2011

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10.1093/cid/cir550

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title = "Initial recovery and rebound of type F intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin",

abstract = "Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.",

author = "Fagan, \{Ryan P.\} and Neil, \{Karen P.\} and Randy Sasich and Carolina Luquez and Hakam Asaad and Susan Maslanka and Wajahat Khalil",

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T1 - Initial recovery and rebound of type F intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin

AU - Fagan, Ryan P.

AU - Neil, Karen P.

AU - Sasich, Randy

AU - Luquez, Carolina

AU - Asaad, Hakam

AU - Maslanka, Susan

AU - Khalil, Wajahat

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.

AB - Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.

UR - https://www.scopus.com/pages/publications/80054056061

UR - https://www.scopus.com/pages/publications/80054056061#tab=citedBy

U2 - 10.1093/cid/cir550

DO - 10.1093/cid/cir550

M3 - Article

C2 - 21896700

AN - SCOPUS:80054056061

SN - 1058-4838

VL - 53

SP - e125-e128

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 9

ER -

Initial recovery and rebound of type F intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin

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