Initial recovery and rebound of type F intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin

Ryan P. Fagan, Karen P. Neil, Randy Sasich, Carolina Luquez, Hakam Asaad, Susan Maslanka, Wajahat Khalil

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.

Original languageEnglish (US)
JournalClinical Infectious Diseases
Volume53
Issue number9
DOIs
StatePublished - Nov 1 2011

Fingerprint

Botulinum Antitoxin
Botulism
Antitoxins
Horses
Immunoglobulins
Immunoglobulin G

Cite this

Initial recovery and rebound of type F intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin. / Fagan, Ryan P.; Neil, Karen P.; Sasich, Randy; Luquez, Carolina; Asaad, Hakam; Maslanka, Susan; Khalil, Wajahat.

In: Clinical Infectious Diseases, Vol. 53, No. 9, 01.11.2011.

Research output: Contribution to journalArticle

Fagan, Ryan P. ; Neil, Karen P. ; Sasich, Randy ; Luquez, Carolina ; Asaad, Hakam ; Maslanka, Susan ; Khalil, Wajahat. / Initial recovery and rebound of type F intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin. In: Clinical Infectious Diseases. 2011 ; Vol. 53, No. 9.
@article{4146954f9a9e45f7be1f24c2d6881866,
title = "Initial recovery and rebound of type F intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin",
abstract = "Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.",
author = "Fagan, {Ryan P.} and Neil, {Karen P.} and Randy Sasich and Carolina Luquez and Hakam Asaad and Susan Maslanka and Wajahat Khalil",
year = "2011",
month = "11",
day = "1",
doi = "10.1093/cid/cir550",
language = "English (US)",
volume = "53",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Initial recovery and rebound of type F intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin

AU - Fagan, Ryan P.

AU - Neil, Karen P.

AU - Sasich, Randy

AU - Luquez, Carolina

AU - Asaad, Hakam

AU - Maslanka, Susan

AU - Khalil, Wajahat

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.

AB - Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.

UR - http://www.scopus.com/inward/record.url?scp=80054056061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054056061&partnerID=8YFLogxK

U2 - 10.1093/cid/cir550

DO - 10.1093/cid/cir550

M3 - Article

C2 - 21896700

AN - SCOPUS:80054056061

VL - 53

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 9

ER -