TY - GEN
T1 - Initial performance of the RatCAP, a PET camera for conscious rat brain imaging
AU - Vaska, P.
AU - Woody, C. L.
AU - Schlyer, D. J.
AU - Radeka, V.
AU - O'Connor, P.
AU - Pratte, J. F.
AU - Shokouhi, S.
AU - Stoll, S. P.
AU - Junnarkar, S. S.
AU - Purschke, M.
AU - Park, S. J.
AU - Southekal, S.
AU - Dzhordzhadze, V.
AU - Schiffer, W.
AU - Neill, J.
AU - Murphy, M.
AU - Aubele, T.
AU - Kristiansen, R.
AU - Villanueva, A.
AU - Boose, S.
AU - Kandasamy, A.
AU - Yu, B.
AU - Kriplani, A.
AU - Krishnamoorthy, S.
AU - Lecomte, R.
AU - Fontaine, R.
PY - 2005
Y1 - 2005
N2 - The first fully functional prototype of the RatCAP (Rat Conscious Animal PET) scanner has been constructed and preliminary evaluations have been performed. RatCAP is a miniature, high performance PET scanner designed specifically to image the brain of a rat while directly attached to its head. The goal is to eliminate the need for anesthesia which can confound quantitative brain studies and prevent simultaneous correlations of neurochemistry and behavior. RatCAP is a fully 3D tomograph with a transaxial (axial) field-of-view of 38 (18) mm, outside diameter 72 mm, and weight <200 g which is supported by a small tether. A total of 384 LSO crystals are divided among 12 independent detector blocks, each of which contains an avalanche photodiode (APD) photosensor array and a custom-designed ASIC for highly integrated front-end processing. A custom FPGA-based time-stamp module has been designed and implemented, achieving a preliminary system resolution of 13.9 ns FWHM. With a point source in the FOV center, spatial resolution is 2.1 mm FWHM, energy resolution averages 23% FWHM, and sensitivity is 0.7% at an average threshold of 150 keV. Novel offline data processing algorithms have been developed including methods for time and energy calibrations, corrections for physical effects, and a highly accurate iterative image reconstruction. Initial phantom and rat brain images have been obtained.
AB - The first fully functional prototype of the RatCAP (Rat Conscious Animal PET) scanner has been constructed and preliminary evaluations have been performed. RatCAP is a miniature, high performance PET scanner designed specifically to image the brain of a rat while directly attached to its head. The goal is to eliminate the need for anesthesia which can confound quantitative brain studies and prevent simultaneous correlations of neurochemistry and behavior. RatCAP is a fully 3D tomograph with a transaxial (axial) field-of-view of 38 (18) mm, outside diameter 72 mm, and weight <200 g which is supported by a small tether. A total of 384 LSO crystals are divided among 12 independent detector blocks, each of which contains an avalanche photodiode (APD) photosensor array and a custom-designed ASIC for highly integrated front-end processing. A custom FPGA-based time-stamp module has been designed and implemented, achieving a preliminary system resolution of 13.9 ns FWHM. With a point source in the FOV center, spatial resolution is 2.1 mm FWHM, energy resolution averages 23% FWHM, and sensitivity is 0.7% at an average threshold of 150 keV. Novel offline data processing algorithms have been developed including methods for time and energy calibrations, corrections for physical effects, and a highly accurate iterative image reconstruction. Initial phantom and rat brain images have been obtained.
UR - https://www.scopus.com/pages/publications/33846627843
UR - https://www.scopus.com/inward/citedby.url?scp=33846627843&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2005.1596971
DO - 10.1109/NSSMIC.2005.1596971
M3 - Conference contribution
AN - SCOPUS:33846627843
SN - 0780392213
SN - 9780780392212
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 3040
EP - 3044
BT - 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
T2 - Nuclear Science Symposium Conference Record, 2005 IEEE
Y2 - 23 October 2005 through 29 October 2005
ER -