Initial performance of the RatCAP, a PET camera for conscious rat brain imaging

P. Vaska, C. L. Woody, D. J. Schlyer, V. Radeka, P. O'Connor, J. F. Pratte, S. Shokouhi, S. P. Stoll, S. S. Junnarkar, M. Purschke, S. J. Park, S. Southekal, V. Dzhordzhadze, W. Schiffer, J. Neill, M. Murphy, T. Aubele, R. Kristiansen, A. Villanueva, S. BooseA. Kandasamy, B. Yu, A. Kriplani, S. Krishnamoorthy, R. Lecomte, R. Fontaine

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

The first fully functional prototype of the RatCAP (Rat Conscious Animal PET) scanner has been constructed and preliminary evaluations have been performed. RatCAP is a miniature, high performance PET scanner designed specifically to image the brain of a rat while directly attached to its head. The goal is to eliminate the need for anesthesia which can confound quantitative brain studies and prevent simultaneous correlations of neurochemistry and behavior. RatCAP is a fully 3D tomograph with a transaxial (axial) field-of-view of 38 (18) mm, outside diameter 72 mm, and weight <200 g which is supported by a small tether. A total of 384 LSO crystals are divided among 12 independent detector blocks, each of which contains an avalanche photodiode (APD) photosensor array and a custom-designed ASIC for highly integrated front-end processing. A custom FPGA-based time-stamp module has been designed and implemented, achieving a preliminary system resolution of 13.9 ns FWHM. With a point source in the FOV center, spatial resolution is 2.1 mm FWHM, energy resolution averages 23% FWHM, and sensitivity is 0.7% at an average threshold of 150 keV. Novel offline data processing algorithms have been developed including methods for time and energy calibrations, corrections for physical effects, and a highly accurate iterative image reconstruction. Initial phantom and rat brain images have been obtained.

Original languageEnglish (US)
Title of host publication2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Pages3040-3044
Number of pages5
DOIs
StatePublished - Dec 1 2005
EventNuclear Science Symposium Conference Record, 2005 IEEE - , Puerto Rico
Duration: Oct 23 2005Oct 29 2005

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume5
ISSN (Print)1095-7863

Other

OtherNuclear Science Symposium Conference Record, 2005 IEEE
CountryPuerto Rico
Period10/23/0510/29/05

Fingerprint Dive into the research topics of 'Initial performance of the RatCAP, a PET camera for conscious rat brain imaging'. Together they form a unique fingerprint.

Cite this