Initial human experience with the Amplatzer perimembranous ventricular septal occluder device

John L Bass, G. S. Kalra, Ramesh Arora, Jozef Masura, Pavlo Gavora, Basil D. Thanopoulos, William Torres, Horst Sievert, Mario Carminati, Gunther Fischer, Peter Ewert

Research output: Contribution to journalArticle

157 Scopus citations

Abstract

Transcatheter closure of perimembranous ventricular septal defects with coils or devices designed to close other lesions may be complicated by embolization or aortic insufficiency. A new asymmetric Amplatzer perimembranous ventricular septal occluder and delivery system was specifically designed for perimembranous defects. This report describes the first use of this device in 27 patients. Implantation was successful in 25 (93%), with 1 removed for device-related aortic insufficiency and inability to position the delivery sheath in another. Device orientation was excellent when the device was initially advanced through a standard delivery sheath positioned in the left ventricular apex. Twenty-three had complete occlusion within 1 week (92%), with a tiny (< 2 mm) residual shunt in the other two. In the 25 subjects with the device left in place, device-related aortic or tricuspid insufficiency, arrhythmias, and embolization were not observed. These excellent acute results need to be confirmed by long-term follow-up.

Original languageEnglish (US)
Pages (from-to)238-245
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Volume58
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Catheterization
  • Heart septal defects
  • Shunts

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    Bass, J. L., Kalra, G. S., Arora, R., Masura, J., Gavora, P., Thanopoulos, B. D., Torres, W., Sievert, H., Carminati, M., Fischer, G., & Ewert, P. (2003). Initial human experience with the Amplatzer perimembranous ventricular septal occluder device. Catheterization and Cardiovascular Interventions, 58(2), 238-245. https://doi.org/10.1002/ccd.10406