Inhibitory influence of catecholamines on prolactin release in the turkey (Meleagris gallopavo)

M E Elhalawani, J. L. Silsby, S. C. Fehrer, E. J. Behnke

Research output: Contribution to journalArticle

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Abstract

The involvement of catecholamines (CAs) in the control of prolactin (PRL) secretion was investigated in female turkeys. The birds were treate with dl-α-methyltyrosine methyl ester HCl (α-MT; 10, 100, or 200 mg/kg), diethyldithiocarbamate (DDC; 200 or 400 mg/kg), or phentolamine (5, 10, and 20 mg/kg), all antiadrenergic drugs. Reduction in central CAs by α-MT or DDC, or blockade of adrenergic receptors by phentolamine resulted in elevated serum PRL levels in a dose-dependent manner. Prior administration of the adrenergic stimulant clonidine (15, 150, or 1500 μg/kg) attenuated the elevated PRL response to phentolamine (20 mg/kg). These results are consistent with the view that the release of PRL in the turkey may be under the inhibitory influence of an adrenergic system.

Original languageEnglish (US)
Pages (from-to)339-343
Number of pages5
JournalGeneral and Comparative Endocrinology
Volume54
Issue number3
DOIs
Publication statusPublished - Jun 1984

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