Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation

Margaret Barthelman, Weixing Chen, Helen L. Gensler, Chuanshu Huang, Zigang Dong, G. Tim Bowden

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

The monoterpene perillyl alcohol (POH) has proven efficacious against the formation and progression of a variety of cancers. In this study, we tested the ability of POH to inhibit photocarcinogenesis in a nonmelanoma model of mouse skin carcinogenesis and its ability to inhibit UVB-induced activator protein 1 (AP-1) transactivation in mouse skin and human keratinocytes. POH (10 mM) was applied topically to the cars and shaved dorsal surface of groups of 35 BALB/c mice throughout the experiment, during and after UVB treatment. Topical POll significantly inhibited tumor incidence and multiplicity, average tumor size, and the average tumor burden/mouse without any apparent toxicity. POH inhibited UVB-induced AP-1 transactivation in both cultured human keratinocytes and transgenic mice that stably express a luciferase reporter driven by AP-1 elements. The results suggest that POll might be used for chemoprevention of human skin cancer, and that inhibition of AP-1 activity is functionally related to inhibition of skin carcinogenesis.

Original languageEnglish (US)
Pages (from-to)711-716
Number of pages6
JournalCancer Research
Volume58
Issue number4
StatePublished - Feb 15 1998

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