Inhibitory effects of eutigosides isolated from Eurya emarginata on the inflammatory mediators in RAW264.7 cells

Soo Yeong Park, Hye Ja Lee, Weon Jong Yoon, Gyoung Jin Kang, Ji Young Moon, Nam Ho Lee, Se Jae Kim, Hee Kyoung Kang, Eun Sook Yoo

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The anti-inflammatory activity of Eurya emarginata (Thumb) Makino, of which leaves have been traditionally used to treat ulcers or diuretic in Jeju Island, has been investigated in the present study. Through the phytochemical study from the methanol extract of E. emaginiata, eutigosides B and C were isolated as the active components. Sseveral inflammatory markers including TNF-α, IL-1β, IL-6, NO, iNOS, and COX-2 were examined. Eutigosides B and C potentially inhibited production of pro-inflammatory cytokines (IL-6 and TNF-α) in a dose-dependent manner. Additionally, the intracellular contents of iNOS protein were markedly decreased after treatment with eutigosides B and C. The inhibition of iNOS activity was correlated with the decrease in nitrite levels. These results suggest that eutigoside B and C from E. emarginata may have anti-inflammatory activity through the inhibition of pro-inflammatory cytokines (TNF-α and IL-6), iNOS and COX-2.

Original languageEnglish (US)
Pages (from-to)1244-1250
Number of pages7
JournalArchives of Pharmacal Research
Volume28
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

Keywords

  • COX-2
  • Eutigoside B
  • Eutigoside C
  • Pro-inflammatory cytokines
  • iNOS

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