Inhibitors of insulin-like growth factor signaling: A therapeutic approach for breast cancer

Research output: Contribution to journalReview article

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Abstract

The peptide growth factors IGF-I and IGF-II not only play a role in the development of the mammary gland but are also implicated in breast cancer. Several reagents disrupting IGF signaling have been developed and clinical trials validating IGF signaling as a target in cancer therapy are underway. This review highlights the approaches to inhibiting IGF signaling in breast cancer.

Original languageEnglish (US)
Pages (from-to)27-39
Number of pages13
JournalJournal of mammary gland biology and neoplasia
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • Antibodies
  • Breast cancer
  • Insulin-like growth factors
  • Small molecule inhibitors
  • Targeted therapy
  • TypeI IGF receptor

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