Inhibition of visceral pain by electrical stimulation of the periaqueductal gray matter

Glenn J. Giesler, John C. Liebeskind

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Numerous recent studies have demonstrated that electrical stimulation of the periaqueductal gray matter (PGM) can result in powerful analgesia to pain of somatic origin. In the present study, we have developed a visceral pain test employing intraperitoneal injection of hypertonic saline which yields a writhing response in the adult rat more reliably than other painproducing substances. With this test we show that writhing as well as the response to radiant heat (tail flick test) are completely inhibited in all animals with PGM electrode placements.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalPain
Volume2
Issue number1
DOIs
StatePublished - Mar 1976

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