Inhibition of ultraviolet C irradiation-induced AP-1 activity by aspirin is through inhibition of JNKs but not Erks or P38 MAP kinase

Wei-Ya Ma, Chaunshu Huang, Zigang Dong

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The exposure of mammalian cells to ultraviolet (UV) irradiation leads to the activation of transcription factors, such as AP-1 and NFκB. We demonstrate that aspirin, a promising cancer chemopreventative agent, inhibited UVC-induced AP-1 activity in JB6 cells. In JB6 cells, UVC stimulated Erks, JNKs and P38 kinase activities; aspirin only inhibited activation of JNKs, but not the other MAP kinases. Since the transcription factor AP-1 is important for the process of tumor promotion, the inhibitory effect of aspirin on AP-1 activation suggests that it can be used as a chemopreventative agent against skin cancer.

Original languageEnglish (US)
Pages (from-to)565-568
Number of pages4
JournalInternational Journal of Oncology
Volume12
Issue number3
DOIs
StatePublished - Mar 1998

Keywords

  • AP-1
  • Aspirin
  • MAP kinase
  • Ultraviolet C

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