Inhibition of RNA slow viruses by thiosemicarbazones

Ashley T. Haase, Warren Levinson

Research output: Contribution to journalArticlepeer-review


N-methyl isatin β-thiosemicarbazone (Methisazone) effects comparable reductions in the reverse transcriptase activity and the cytopathic effect of the RNA slow viruses, Visna, Maedi and Progressive Pneumonia Virus. This is consistent with a requirement for RNA-dependent DNA synthesis in a lytic (non-transforming) cycle of virus growth.

Original languageEnglish (US)
Pages (from-to)875-880
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Apr 16 1973


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