N-methyl isatin β-thiosemicarbazone (Methisazone) effects comparable reductions in the reverse transcriptase activity and the cytopathic effect of the RNA slow viruses, Visna, Maedi and Progressive Pneumonia Virus. This is consistent with a requirement for RNA-dependent DNA synthesis in a lytic (non-transforming) cycle of virus growth.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Apr 16 1973|