Inhibition of retinoid activity by components of a paper mill effluent

Patrick K Schoff, Gerald T. Ankley

Research output: Contribution to journalArticle

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Abstract

A cell line stably transfected with reporter genes activated by retinoic acid was used to test a paper mill effluent for the presence of retinoids or components that interfere with retinoic acid-stimulated gene transcription. No retinoids were detected in effluent or control water. However, effluent water significantly decreased reporter activity stimulated by all-trans-retinoic acid, while activity stimulated by 9-cis-retinoic acid was unaffected. In a limited fractionation through a C-18 solid phase-exchange column the inhibitory activity was retained in the aqueous fraction, indicating that the activity was polar.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalEnvironmental Pollution
Volume119
Issue number1
DOIs
StatePublished - Mar 20 2002

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Keywords

  • RAR
  • RXR
  • Transfected cells

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