Inhibition of Renin by Substrate Analogue Inhibitors Containing the Olefinic Amino Acid 5(S)-Amino-7-Methyl-3(E)-octenoic Acid

Rodney L. Johnson

Research output: Contribution to journalArticle

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Abstract

The olefinic dipeptide 5(S)-amino-7-methyl-3(E)-octenoic acid (1) was synthesized and used to make the olefinic peptides Leuφ[CH=CH]Gly-Val-Phe-OCH3 (2) and His-Leuφ[E-CH=CH]Gly-Val-Phe-OCH3 (3). These olefinic peptides were found to exhibit renin inhibitory activity against both hog kidney renin and human amniotic renin that was comparable to the substrate analogue inhibitors Leu-Leu-Val-Phe-OCH3 and His-Leu-Leu-Val-Phe-OCH3.

Original languageEnglish (US)
Pages (from-to)1351-1354
Number of pages4
JournalJournal of medicinal chemistry
Volume27
Issue number10
DOIs
StatePublished - Dec 1984

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