Inhibitors of oncogene product enzyme activity were sought as a prescreen for potential cancer chemopreventive agents. Daphnoretin, a dicoumaryl ether from Thymelaea hirsuta root, inhibited the erb-b oncogene product, the tyrosine-specific protein kinase of human epidermal growth factor receptor (IC50 = 97.5 μM). Daphnoretin was moderately cytotoxic (IC50 = 21-114 μM) only in rapidly proliferating cultured mammalian cells.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jun 1 1998|
- Cultured mammalian cells
- Thymelaea hirsuta (L.) Endl.
- Tyrosine kinase inhibition