Inhibition of nicotine-induced seizures in rats by combining vaccination against nicotine with chronic nicotine infusion

Yesim Tuncok, Yoko Hieda, Daniel E. Keyler, Scott Brown, Sofiane Ennifar, Ali Fattom, Paul R. Pentel

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The ability of a nicotine vaccine to protect against nicotine-induced seizures was studied in rats. Groups of 10 rats were vaccinated with 3 doses of either a nicotine conjugate vaccine over 6 weeks to elicit high titers of nicotine-specific antibodies or with a control vaccine. Rats were then pretreated with a 1-week subcutaneous infusion of either nicotine 1 mg/kg/day or saline and then received a single 2 mg/kg ip dose of nicotine to provoke seizures. Vaccination reduced the incidence of seizures. The combination of vaccination and pretreatment with nicotine infusion was more effective than either treatment alone. These data suggest that vaccination is protective against this toxic effect of nicotine and that combining vaccination and chronic nicotine administration may provide a novel strategy for blocking some effects of nicotine.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalExperimental and Clinical Psychopharmacology
Volume9
Issue number2
DOIs
StatePublished - 2001

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