Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease

Matthew J. Pollman, Jennifer L. Hall, Michael J. Mann, Lunan Zhang, Gary H. Gibbons

Research output: Contribution to journalArticlepeer-review

254 Scopus citations

Abstract

We postulated that activation of a genetic program that tonically inhibits intimal cell death is a necessary condition for the pathogenesis of vascular disease. Studies of vascular lesions in humans and animal models documented increased expression of the anti-apoptotic gene product Bcl-x(L) within intimal cells. Downregulation of intimal cell bcl-x(L) expression with the use of antisense oligonucleotides induced apoptosis and acute regression of vascular lesions. These findings indicate that apoptosis regulatory genes such as bcl-x(L) are critical determinants of intimal lesion formation and that targeted apoptosis may be a novel therapy for intimal vascular disease.

Original languageEnglish (US)
Pages (from-to)222-227
Number of pages6
JournalNature Medicine
Volume4
Issue number2
DOIs
StatePublished - Apr 7 1998

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