Inhibition of in vitro protein synthesis by a carbocyclic puromycin analog

Robert Vince, Susan Daluge, Maxine Palm

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The effect of a novel puromycin analog (I) on the poly U and poly UC directed polyphenylalanine synthesis has been examined. The inhibition of both systems by I corresponded with the inhibitory activities of puromycin. The carbocyclic analog also demonstrated inhibitory activity in three tumor systems grown in tissue culture.

Original languageEnglish (US)
Pages (from-to)866-870
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume46
Issue number2
DOIs
StatePublished - Jan 31 1972

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