Inhibition of in vitro protein synthesis by a carbocyclic puromycin analog

Robert Vince; Susan Daluge; Maxine Palm

doi:10.1016/S0006-291X(72)80221-3

Inhibition of in vitro protein synthesis by a carbocyclic puromycin analog

Robert Vince, Susan Daluge, Maxine Palm

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

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Abstract

The effect of a novel puromycin analog (I) on the poly U and poly UC directed polyphenylalanine synthesis has been examined. The inhibition of both systems by I corresponded with the inhibitory activities of puromycin. The carbocyclic analog also demonstrated inhibitory activity in three tumor systems grown in tissue culture.

Original language	English (US)
Pages (from-to)	866-870
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(72)80221-3
State	Published - Jan 31 1972

Bibliographical note

Funding Information:
the U.S. Public Health Service and Grant CAI0979 from the National Cancer

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10.1016/S0006-291X(72)80221-3

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title = "Inhibition of in vitro protein synthesis by a carbocyclic puromycin analog",

abstract = "The effect of a novel puromycin analog (I) on the poly U and poly UC directed polyphenylalanine synthesis has been examined. The inhibition of both systems by I corresponded with the inhibitory activities of puromycin. The carbocyclic analog also demonstrated inhibitory activity in three tumor systems grown in tissue culture.",

author = "Robert Vince and Susan Daluge and Maxine Palm",

note = "Funding Information: the U.S. Public Health Service and Grant CAI0979 from the National Cancer",

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AU - Daluge, Susan

AU - Palm, Maxine

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AB - The effect of a novel puromycin analog (I) on the poly U and poly UC directed polyphenylalanine synthesis has been examined. The inhibition of both systems by I corresponded with the inhibitory activities of puromycin. The carbocyclic analog also demonstrated inhibitory activity in three tumor systems grown in tissue culture.

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Inhibition of in vitro protein synthesis by a carbocyclic puromycin analog

Abstract

Bibliographical note

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