Inhibition of Epstein-Barr Virus by the triterpenoid betulin diphosphate and uvaol

Muhammad Amjad; Robert M Carlson; Pavel Krasutsky; M. Reza Ul Karim

Inhibition of Epstein-Barr Virus by the triterpenoid betulin diphosphate and uvaol

Muhammad Amjad
, Robert M Carlson
, Pavel Krasutsky
, M. Reza Ul Karim

Chemistry & Biochemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Betulin, a pentacyclic triterpenoid isolated from the bark of Betula papyrifera. Laboratory synthesized structural analogs were tested for antiviral activities against Epstein-Barr Virus (EBV) by immunofluorescent antiviral assay. Among the several analogs tested, betulin 3,28-diphosphate and uvaol exhibited significant antiviral activities against EBV. The EC₅₀ of betulin 3,28-diphosphate and uvaol was found to be 0.6 μM and 0.7 μM, respectively.

Original language	English (US)
Pages (from-to)	1086-1088
Number of pages	3
Journal	Journal of Microbiology and Biotechnology
Volume	14
Issue number	5
State	Published - Oct 2004

Keywords

Antiviral
Epstein-Barr Virus (EBV)
Triterpenoid

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title = "Inhibition of Epstein-Barr Virus by the triterpenoid betulin diphosphate and uvaol",

abstract = "Betulin, a pentacyclic triterpenoid isolated from the bark of Betula papyrifera. Laboratory synthesized structural analogs were tested for antiviral activities against Epstein-Barr Virus (EBV) by immunofluorescent antiviral assay. Among the several analogs tested, betulin 3,28-diphosphate and uvaol exhibited significant antiviral activities against EBV. The EC50 of betulin 3,28-diphosphate and uvaol was found to be 0.6 μM and 0.7 μM, respectively.",

keywords = "Antiviral, Epstein-Barr Virus (EBV), Triterpenoid",

author = "Muhammad Amjad and Carlson, \{Robert M\} and Pavel Krasutsky and Karim, \{M. Reza Ul\}",

year = "2004",

month = oct,

language = "English (US)",

volume = "14",

pages = "1086--1088",

journal = "Journal of Microbiology and Biotechnology",

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T1 - Inhibition of Epstein-Barr Virus by the triterpenoid betulin diphosphate and uvaol

AU - Amjad, Muhammad

AU - Carlson, Robert M

AU - Krasutsky, Pavel

AU - Karim, M. Reza Ul

PY - 2004/10

Y1 - 2004/10

N2 - Betulin, a pentacyclic triterpenoid isolated from the bark of Betula papyrifera. Laboratory synthesized structural analogs were tested for antiviral activities against Epstein-Barr Virus (EBV) by immunofluorescent antiviral assay. Among the several analogs tested, betulin 3,28-diphosphate and uvaol exhibited significant antiviral activities against EBV. The EC50 of betulin 3,28-diphosphate and uvaol was found to be 0.6 μM and 0.7 μM, respectively.

AB - Betulin, a pentacyclic triterpenoid isolated from the bark of Betula papyrifera. Laboratory synthesized structural analogs were tested for antiviral activities against Epstein-Barr Virus (EBV) by immunofluorescent antiviral assay. Among the several analogs tested, betulin 3,28-diphosphate and uvaol exhibited significant antiviral activities against EBV. The EC50 of betulin 3,28-diphosphate and uvaol was found to be 0.6 μM and 0.7 μM, respectively.

KW - Antiviral

KW - Epstein-Barr Virus (EBV)

KW - Triterpenoid

UR - https://www.scopus.com/pages/publications/8644225856

UR - https://www.scopus.com/pages/publications/8644225856#tab=citedBy

M3 - Article

AN - SCOPUS:8644225856

SN - 1017-7825

VL - 14

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EP - 1088

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

IS - 5

ER -

Inhibition of Epstein-Barr Virus by the triterpenoid betulin diphosphate and uvaol

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Keywords

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