Inhibition of Epstein-Barr Virus by the triterpenoid betulin diphosphate and uvaol

Muhammad Amjad; Robert M Carlson; Pavel Krasutsky; M. Reza Ul Karim

Inhibition of Epstein-Barr Virus by the triterpenoid betulin diphosphate and uvaol

Muhammad Amjad, Robert M Carlson, Pavel Krasutsky, M. Reza Ul Karim

Chemistry & Biochemistry

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Betulin, a pentacyclic triterpenoid isolated from the bark of Betula papyrifera. Laboratory synthesized structural analogs were tested for antiviral activities against Epstein-Barr Virus (EBV) by immunofluorescent antiviral assay. Among the several analogs tested, betulin 3,28-diphosphate and uvaol exhibited significant antiviral activities against EBV. The EC₅₀ of betulin 3,28-diphosphate and uvaol was found to be 0.6 μM and 0.7 μM, respectively.

Original language	English (US)
Pages (from-to)	1086-1088
Number of pages	3
Journal	Journal of Microbiology and Biotechnology
Volume	14
Issue number	5
State	Published - Oct 2004

Keywords

Antiviral
Epstein-Barr Virus (EBV)
Triterpenoid

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abstract = "Betulin, a pentacyclic triterpenoid isolated from the bark of Betula papyrifera. Laboratory synthesized structural analogs were tested for antiviral activities against Epstein-Barr Virus (EBV) by immunofluorescent antiviral assay. Among the several analogs tested, betulin 3,28-diphosphate and uvaol exhibited significant antiviral activities against EBV. The EC50 of betulin 3,28-diphosphate and uvaol was found to be 0.6 μM and 0.7 μM, respectively.",

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AU - Amjad, Muhammad

AU - Carlson, Robert M

AU - Krasutsky, Pavel

AU - Karim, M. Reza Ul

PY - 2004/10

Y1 - 2004/10

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AB - Betulin, a pentacyclic triterpenoid isolated from the bark of Betula papyrifera. Laboratory synthesized structural analogs were tested for antiviral activities against Epstein-Barr Virus (EBV) by immunofluorescent antiviral assay. Among the several analogs tested, betulin 3,28-diphosphate and uvaol exhibited significant antiviral activities against EBV. The EC50 of betulin 3,28-diphosphate and uvaol was found to be 0.6 μM and 0.7 μM, respectively.

KW - Antiviral

KW - Epstein-Barr Virus (EBV)

KW - Triterpenoid

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ER -

Inhibition of Epstein-Barr Virus by the triterpenoid betulin diphosphate and uvaol

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