Inhibition of epithelial ovarian cancer by Minnelide, a water-soluble pro-drug

Colleen Rivard; Melissa A Geller; Erica Schnettler; manju saluja; Rachel I Vogel; Ashok K Saluja; Sundaram Ramakrishnan

doi:10.1016/j.ygyno.2014.08.031

Inhibition of epithelial ovarian cancer by Minnelide, a water-soluble pro-drug

Colleen Rivard, Melissa A Geller, Erica Schnettler, manju saluja, Rachel I Vogel, Ashok K Saluja, Sundaram Ramakrishnan

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Objective Minnelide is a water-soluble pro-drug of triptolide, a natural product. The goal of this study was to evaluate the effectiveness of Minnelide on ovarian cancer growth in vitro and in vivo.

Methods The effect of Minnelide on ovarian cancer cell proliferation was determined by real time electrical impedance measurements. Multiple mouse models with C200 and A2780 epithelial ovarian cancer cell lines were used to assess the efficacy of Minnelide in inhibiting ovarian cancer growth.

Results Minnelide decreased cell viability of both platinum sensitive and resistant epithelial ovarian cancer cells in vitro. Minnelide with carboplatin showed additive effects in vitro. Minnelide monotherapy increased the survival of mice bearing established ovarian tumors. Minnelide, in combination with carboplatin and paclitaxel, improved overall survival of mice.

Conclusions Minnelide is a promising pro-drug for the treatment of ovarian cancer, especially when combined with standard chemotherapy.

Original language	English (US)
Pages (from-to)	318-324
Number of pages	7
Journal	Gynecologic oncology
Volume	135
Issue number	2
DOIs	https://doi.org/10.1016/j.ygyno.2014.08.031
State	Published - Nov 1 2014

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© 2014 Elsevier Inc. All rights reserved.

Keywords

Chemotherapy
Minnelide
Ovarian cancer
Triptolide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Inhibition of epithelial ovarian cancer by Minnelide, a water-soluble pro-drug",

abstract = "Objective Minnelide is a water-soluble pro-drug of triptolide, a natural product. The goal of this study was to evaluate the effectiveness of Minnelide on ovarian cancer growth in vitro and in vivo.Methods The effect of Minnelide on ovarian cancer cell proliferation was determined by real time electrical impedance measurements. Multiple mouse models with C200 and A2780 epithelial ovarian cancer cell lines were used to assess the efficacy of Minnelide in inhibiting ovarian cancer growth.Results Minnelide decreased cell viability of both platinum sensitive and resistant epithelial ovarian cancer cells in vitro. Minnelide with carboplatin showed additive effects in vitro. Minnelide monotherapy increased the survival of mice bearing established ovarian tumors. Minnelide, in combination with carboplatin and paclitaxel, improved overall survival of mice.Conclusions Minnelide is a promising pro-drug for the treatment of ovarian cancer, especially when combined with standard chemotherapy.",

keywords = "Chemotherapy, Minnelide, Ovarian cancer, Triptolide",

author = "Colleen Rivard and Geller, {Melissa A} and Erica Schnettler and manju saluja and Vogel, {Rachel I} and Saluja, {Ashok K} and Sundaram Ramakrishnan",

year = "2014",

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day = "1",

doi = "10.1016/j.ygyno.2014.08.031",

language = "English (US)",

volume = "135",

pages = "318--324",

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T1 - Inhibition of epithelial ovarian cancer by Minnelide, a water-soluble pro-drug

AU - Rivard, Colleen

AU - Geller, Melissa A

AU - Schnettler, Erica

AU - saluja, manju

AU - Vogel, Rachel I

AU - Saluja, Ashok K

AU - Ramakrishnan, Sundaram

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Objective Minnelide is a water-soluble pro-drug of triptolide, a natural product. The goal of this study was to evaluate the effectiveness of Minnelide on ovarian cancer growth in vitro and in vivo.Methods The effect of Minnelide on ovarian cancer cell proliferation was determined by real time electrical impedance measurements. Multiple mouse models with C200 and A2780 epithelial ovarian cancer cell lines were used to assess the efficacy of Minnelide in inhibiting ovarian cancer growth.Results Minnelide decreased cell viability of both platinum sensitive and resistant epithelial ovarian cancer cells in vitro. Minnelide with carboplatin showed additive effects in vitro. Minnelide monotherapy increased the survival of mice bearing established ovarian tumors. Minnelide, in combination with carboplatin and paclitaxel, improved overall survival of mice.Conclusions Minnelide is a promising pro-drug for the treatment of ovarian cancer, especially when combined with standard chemotherapy.

AB - Objective Minnelide is a water-soluble pro-drug of triptolide, a natural product. The goal of this study was to evaluate the effectiveness of Minnelide on ovarian cancer growth in vitro and in vivo.Methods The effect of Minnelide on ovarian cancer cell proliferation was determined by real time electrical impedance measurements. Multiple mouse models with C200 and A2780 epithelial ovarian cancer cell lines were used to assess the efficacy of Minnelide in inhibiting ovarian cancer growth.Results Minnelide decreased cell viability of both platinum sensitive and resistant epithelial ovarian cancer cells in vitro. Minnelide with carboplatin showed additive effects in vitro. Minnelide monotherapy increased the survival of mice bearing established ovarian tumors. Minnelide, in combination with carboplatin and paclitaxel, improved overall survival of mice.Conclusions Minnelide is a promising pro-drug for the treatment of ovarian cancer, especially when combined with standard chemotherapy.

KW - Chemotherapy

KW - Minnelide

KW - Ovarian cancer

KW - Triptolide

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JO - Gynecologic oncology

JF - Gynecologic oncology

IS - 2

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Inhibition of epithelial ovarian cancer by Minnelide, a water-soluble pro-drug

Abstract

Bibliographical note

Keywords

UN SDGs

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