Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol

Ann M. Bode, Wei-Ya Ma, Young Joon Surh, Zigang Dong

Research output: Contribution to journalArticle

143 Scopus citations

Abstract

Many spices, including plants of the ginger family, possess anticarcinogenic activity. However, the molecular mechanisms by which they exert their antitumorigenic effects are unknown. Activator protein 1 (AP-1) has a critical role in tumor promotion, and blocking of tumor promoter-induced activation of AP-1 inhibits neoplastic transformation. Epidermal growth factor induces cell transformation and AP-1 activity. The purpose of this study was to investigate the effect of two structurally related compounds of the ginger family, [6]-gingerol and [6]-paradol, on EGF-induced cell transformation and AP-1 activation. Our results provide the first evidence that both block EGF-induced cell transformation but act by different mechanisms.

Original languageEnglish (US)
Pages (from-to)850-853
Number of pages4
JournalCancer Research
Volume61
Issue number3
StatePublished - Feb 1 2001

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