Inhibition of acetyl phosphate-dependent transcription by an acetylatable lysine on RNA polymerase

Bruno P. Lima, Tran Thi Thanh Huyen, Katrin Bäsell, Dörte Becher, Haike Antelmann, Alan J. Wolfe

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The ability of bacteria to adapt to environmental changes has allowed these organisms to thrive in all parts of the globe. By monitoring their extracellular and intracellular environments, bacteria assure their most appropriate response for each environment. Post-translational modification of proteins is one mechanism by which cells respond to their changing environments. Here, we report that two post-translational modifications regulate transcription of the extracytoplasmic stress-responsive promoter cpxP : (i) acetyl phosphate-dependent phosphorylation of the response regulator CpxR and (ii) acetyl coenzyme A-dependent acetylation of the α subunit of RNA polymerase. Together, these two post-translational modifications fine-tune cpxP transcription in response to changes in the intracellular environment.

Original languageEnglish (US)
Pages (from-to)32147-32160
Number of pages14
JournalJournal of Biological Chemistry
Volume287
Issue number38
DOIs
StatePublished - Sep 14 2012

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