Inhibition of β-Propiolactone-induced Mutagenesis and Neoplasia by Sodium Thiosulfate

Lee W. Wattenberg, J. Bradley Hochalter, Arthur R. Galbraith

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Studies have been initiated to find compounds that can trap direct-acting carcinogens within the stomach. Sodium thiosulfate (STS) is a potent nucleophile and in initial experiments was found to inhibit mutagenesis resulting from exposure of Salmonella typhimurium strain TA100 to the direct-acting carcinogens β-propiolactone and styrene oxide. In in vitro experiments STS was shown to maintain its nucleophilidty in the acid pH range. It reacted with β-propiolactone as rapidly at pH 2 as at pH 7.4. Thus STS has the prerequisite attributes to inhibit the carcinogenic effects of electrophiles in the stomach. Experiments were performed in which STS was administered by p.o. intubation to female A/J mice 5 min before p.o. administration of β-propiolactone. Under these conditions, inhibition of formation of the forestomach tumors occurred. The data obtained suggest that use of nucleophiles to protect against direct-acting carcinogens is a potential strategy for chemoprevention.

Original languageEnglish (US)
Pages (from-to)4351-4354
Number of pages4
JournalCancer Research
Volume47
Issue number16
StatePublished - Jan 1 1987

Fingerprint

Propiolactone
Mutagenesis
Carcinogens
styrene oxide
Neoplasms
Stomach
Chemoprevention
Salmonella typhimurium
Intubation
Acids
sodium thiosulfate

Cite this

Inhibition of β-Propiolactone-induced Mutagenesis and Neoplasia by Sodium Thiosulfate. / Wattenberg, Lee W.; Hochalter, J. Bradley; Galbraith, Arthur R.

In: Cancer Research, Vol. 47, No. 16, 01.01.1987, p. 4351-4354.

Research output: Contribution to journalArticle

Wattenberg, Lee W. ; Hochalter, J. Bradley ; Galbraith, Arthur R. / Inhibition of β-Propiolactone-induced Mutagenesis and Neoplasia by Sodium Thiosulfate. In: Cancer Research. 1987 ; Vol. 47, No. 16. pp. 4351-4354.
@article{37ae38d31d8f49c0abc4c71daf8149eb,
title = "Inhibition of β-Propiolactone-induced Mutagenesis and Neoplasia by Sodium Thiosulfate",
abstract = "Studies have been initiated to find compounds that can trap direct-acting carcinogens within the stomach. Sodium thiosulfate (STS) is a potent nucleophile and in initial experiments was found to inhibit mutagenesis resulting from exposure of Salmonella typhimurium strain TA100 to the direct-acting carcinogens β-propiolactone and styrene oxide. In in vitro experiments STS was shown to maintain its nucleophilidty in the acid pH range. It reacted with β-propiolactone as rapidly at pH 2 as at pH 7.4. Thus STS has the prerequisite attributes to inhibit the carcinogenic effects of electrophiles in the stomach. Experiments were performed in which STS was administered by p.o. intubation to female A/J mice 5 min before p.o. administration of β-propiolactone. Under these conditions, inhibition of formation of the forestomach tumors occurred. The data obtained suggest that use of nucleophiles to protect against direct-acting carcinogens is a potential strategy for chemoprevention.",
author = "Wattenberg, {Lee W.} and Hochalter, {J. Bradley} and Galbraith, {Arthur R.}",
year = "1987",
month = "1",
day = "1",
language = "English (US)",
volume = "47",
pages = "4351--4354",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "16",

}

TY - JOUR

T1 - Inhibition of β-Propiolactone-induced Mutagenesis and Neoplasia by Sodium Thiosulfate

AU - Wattenberg, Lee W.

AU - Hochalter, J. Bradley

AU - Galbraith, Arthur R.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Studies have been initiated to find compounds that can trap direct-acting carcinogens within the stomach. Sodium thiosulfate (STS) is a potent nucleophile and in initial experiments was found to inhibit mutagenesis resulting from exposure of Salmonella typhimurium strain TA100 to the direct-acting carcinogens β-propiolactone and styrene oxide. In in vitro experiments STS was shown to maintain its nucleophilidty in the acid pH range. It reacted with β-propiolactone as rapidly at pH 2 as at pH 7.4. Thus STS has the prerequisite attributes to inhibit the carcinogenic effects of electrophiles in the stomach. Experiments were performed in which STS was administered by p.o. intubation to female A/J mice 5 min before p.o. administration of β-propiolactone. Under these conditions, inhibition of formation of the forestomach tumors occurred. The data obtained suggest that use of nucleophiles to protect against direct-acting carcinogens is a potential strategy for chemoprevention.

AB - Studies have been initiated to find compounds that can trap direct-acting carcinogens within the stomach. Sodium thiosulfate (STS) is a potent nucleophile and in initial experiments was found to inhibit mutagenesis resulting from exposure of Salmonella typhimurium strain TA100 to the direct-acting carcinogens β-propiolactone and styrene oxide. In in vitro experiments STS was shown to maintain its nucleophilidty in the acid pH range. It reacted with β-propiolactone as rapidly at pH 2 as at pH 7.4. Thus STS has the prerequisite attributes to inhibit the carcinogenic effects of electrophiles in the stomach. Experiments were performed in which STS was administered by p.o. intubation to female A/J mice 5 min before p.o. administration of β-propiolactone. Under these conditions, inhibition of formation of the forestomach tumors occurred. The data obtained suggest that use of nucleophiles to protect against direct-acting carcinogens is a potential strategy for chemoprevention.

UR - http://www.scopus.com/inward/record.url?scp=0023278375&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023278375&partnerID=8YFLogxK

M3 - Article

C2 - 3607767

AN - SCOPUS:0023278375

VL - 47

SP - 4351

EP - 4354

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 16

ER -