Inhibition of β-Propiolactone-induced Mutagenesis and Neoplasia by Sodium Thiosulfate

Lee W. Wattenberg, J. Bradley Hochalter, Arthur R. Galbraith

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Studies have been initiated to find compounds that can trap direct-acting carcinogens within the stomach. Sodium thiosulfate (STS) is a potent nucleophile and in initial experiments was found to inhibit mutagenesis resulting from exposure of Salmonella typhimurium strain TA100 to the direct-acting carcinogens β-propiolactone and styrene oxide. In in vitro experiments STS was shown to maintain its nucleophilidty in the acid pH range. It reacted with β-propiolactone as rapidly at pH 2 as at pH 7.4. Thus STS has the prerequisite attributes to inhibit the carcinogenic effects of electrophiles in the stomach. Experiments were performed in which STS was administered by p.o. intubation to female A/J mice 5 min before p.o. administration of β-propiolactone. Under these conditions, inhibition of formation of the forestomach tumors occurred. The data obtained suggest that use of nucleophiles to protect against direct-acting carcinogens is a potential strategy for chemoprevention.

Original languageEnglish (US)
Pages (from-to)4351-4354
Number of pages4
JournalCancer Research
Volume47
Issue number16
StatePublished - Aug 1987

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