Inhibition facilitates direction selectivity in a noisy cortical environment

Audrey Sederberg, Matthias Kaschube

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In a broad class of models, direction selectivity in primary visual cortical neurons arises from the linear summation of spatially offset and temporally lagged inputs combined with a spike threshold. Here, we characterize the robustness of this class of models to input noise and background activity that is uncorrelated with the visual stimulus. When only excitatory inputs were considered, moderate levels of noise substantially degraded direction selectivity. By contrast, the inclusion of inhibition produced a direction-selective neuron even at high noise levels. Moreover, if inhibitory inputs were tuned, mirroring excitatory inputs but lagging by a fixed delay, they promoted a highly direction-selective response by suppressing all excitatory inputs in the null direction while minimally affecting excitatory inputs in the preferred direction. Additionally, tuned inhibition strongly reduced trial-by-trial variability, such that the neuron produced a consistent direction-selective response to multiple presentation of the same stimulus. This work illustrates how inhibition could be used by cortical circuits to reliably extract information on a single-trial basis from feed-forward inputs in a noisy, high-background context.

Original languageEnglish (US)
Pages (from-to)235-248
Number of pages14
JournalJournal of Computational Neuroscience
Volume38
Issue number2
DOIs
StatePublished - Apr 2015
Externally publishedYes

Bibliographical note

Funding Information:
The authors thank Stephanie E. Palmer for helpful comments on the manuscript. This work is supported by NIH training grant 5T32HG003284, NIH grant P50 GM071508 (PI David Botstein) and Bernstein Focus: Neurotechnology Frankfurt, BFNT 01GQ0840.

Publisher Copyright:
© 2014, Springer Science+Business Media New York.

Keywords

  • Background noise
  • Cortical direction selectivity models
  • Role of inhibition

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