Abstract
A non-immune complex-mediated glomerulonephritis associated with persistent hypocomplementemia occurred in a young boy. Measurement of complement components revealed complete factor H deficiency, inherited as an autosomal recessive trait. Evaluation of the renal lesion revealed extensive deposition of type III collagen suggestive of collagen type III glomerulopathy, a recently identified cause of chronic renal insufficiency in children and adults. This report represents the first association of inherited factor H deficiency with collagen type III glomerulopathy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-15 |
| Number of pages | 5 |
| Journal | Pediatric Nephrology |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1995 |
Keywords
- Collagen type III glomerulopathy
- Complement
- Factor H
- Glomerulonephritis
- β-1 H globulin