Inherited coagulation disorders in southern Iran

M. Karimi, R. Ardeshiri, Hirad Yarmohammadi

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

A comprehensive survey concerning the Shiraz Hemophilia Society and the associated haemophilia treatment centre was undertaken in April 2002 to collect data on demographics, signs and symptoms in the southern Iranian population with haemophilia and allied disorders. The total number of patients with coagulation disorders was 367. Haemophilia A (factor [F] VIII deficiency) was found in 271, 39 had haemophilia B (FIX deficiency) and 24 had von Willebrand disease. The rare coagulation disorders (n = 33) included 11 patients with FX deficiency; 10 with FVII; six with FXIII; two with afibrinogenaemia; two with FXI; one with combined FVIII and FV; and one with combined FVII, FVIII and FIX deficiency. The prevalence was 6.64 per 100 000 inhabitants. The most common symptoms were haemarthrosis, haematomas and epistaxis. None of the patients were human immunodeficiency virus positive but 47 (15%) were hepatitis C virus positive and two (0.7%) were hepatitis B positive, so that the rate of transfusion-transmitted infections was lower compared with other populations.

Original languageEnglish (US)
Pages (from-to)740-744
Number of pages5
JournalHaemophilia
Volume8
Issue number6
DOIs
StatePublished - Jan 1 2002

Keywords

  • Haemophilia
  • Hereditary bleeding disorders
  • Rare coagulation disorders
  • Shiraz Hemophilia society
  • Southern Iran

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