Inheritance of rupture of the cranial cruciate ligament in Newfoundlands

Vicki L. Wilke, Michael G. Conzemius, Brian P. Kinghorn, Paula E. Macrossan, Weiguo Cai, Max F. Rothschild

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72 Scopus citations

Abstract

Objective - To determine prevalence, level of inbreeding, heritability, and mode of inheritance for rupture of the cranial cruciate ligament (RCCL) in Newfoundlands. Design - Retrospective and recruitment study. Animals-574 client-owned Newfoundlands. Procedure - Medical records from January 1, 1996, to December 31, 2002, were evaluated for prevalence of RCCL. A pedigree was constructed by use of recruited Newfoundlands with RCCL status based on results of veterinary examination; level of inbreeding, heritability, and mode of inheritance were calculated. Results - Hospital prevalence for RCCL was 22%; dogs in the pedigree from the recruitment study had a mean level of inbreeding of 1.19 × 10-4, heritability of 0.27, and a possible recessive mode of inheritance with 51% penetrance for RCCL. Conclusions and Clinical Relevance - Identification of a genetic basis for RCCL in Newfoundlands provided evidence that investigators can now focus on developing methods to identify carriers to reduce the prevalence of RCCL.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalJournal of the American Veterinary Medical Association
Volume228
Issue number1
DOIs
StatePublished - Jan 1 2006

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