Inhalable magnetic nanoparticles for targeted hyperthermia in lung cancer therapy

Tanmoy Sadhukha, Timothy S. Wiedmann, Jayanth Panyam

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

Lung cancer (specifically, non-small cell lung cancer; NSCLC) is the leading cause of cancer-related deaths in the United States. Poor response rates and survival with current treatments clearly indicate the urgent need for developing an effective means to treat NSCLC. Magnetic hyperthermia is a non-invasive approach for tumor ablation, and is based on heat generation by magnetic materials, such as superparamagnetic iron oxide (SPIO) nanoparticles, when subjected to an alternating magnetic field. However, inadequate delivery of magnetic nanoparticles to tumor cells can result in sub-lethal temperature change and induce resistance while non-targeted delivery of these particles to the healthy tissues can result in toxicity. In our studies, we evaluated the effectiveness of tumor-targeted SPIO nanoparticles for magnetic hyperthermia of lung cancer. EGFR-targeted, inhalable SPIO nanoparticles were synthesized and characterized for targeting lung tumor cells as well as for magnetic hyperthermia-mediated antitumor efficacy in a mouse orthotopic model of NSCLC. Our results show that EGFR targeting enhances tumor retention of SPIO nanoparticles. Further, magnetic hyperthermia treatment using targeted SPIO nanoparticles resulted in significant inhibition of invivo lung tumor growth. Overall, this work demonstrates the potential for developing an effective anticancer treatment modality for the treatment of NSCLC based on targeted magnetic hyperthermia.

Original languageEnglish (US)
Pages (from-to)5163-5171
Number of pages9
JournalBiomaterials
Volume34
Issue number21
DOIs
StatePublished - Jul 1 2013

Keywords

  • EGFR
  • Inhalation delivery
  • Lung cancer
  • Magnetic hyperthermia
  • Superparamagnetic iron oxide

Fingerprint Dive into the research topics of 'Inhalable magnetic nanoparticles for targeted hyperthermia in lung cancer therapy'. Together they form a unique fingerprint.

Cite this