Infrared spectroscopic study of ethanol-induced changes in rat liver plasma membrane

E. Neil Lewis, Ira W. Levin, Clifford J. Steer

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Vibrational infrared spectroscopy, a noninvasive method for probing the structural and dynamic properties of biological membranes, is used to characterize the in vivo and in vitro perturbations of ethanol on various liver plasma membrane preparations derived from alcohol-treated rats. Spectral frequency shifts of the bilayer lipid chain methylene carbon-hydrogen symmetric stretching modes indicate that the adaptive response of the liver plasma membranes of the alcohol-treated animals results in an increase in membrane order on the vibrational time scale. Additional in vitro ethanol treatment of these membrane preparations leads to further significant increases in bilayer order. The observed membrane ordering effects are consistent with a bilayer model of partial interdigitation, or chain overlap, of the opposing membrane monolayers near the bilayer center.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalBBA - Biomembranes
Issue number1
StatePublished - Nov 17 1989


  • Ethanol
  • Infrared spectroscopy
  • Interdigitated lipid chain
  • Liver plasma membrane
  • Membrane order


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