Objectives: To determine if the clinical characteristics of children with gastroenteritis and influenza identified in their stool differ from those whose stool was influenza-negative. Methods: Children <18-years with gastroenteritis whose stool tested negative for enteropathogen were tested for influenza in stool. The clinical features between influenza-positive and influenza-negative gastroenteritis cases were compared. Stools from controls without infection were also tested for influenza. Results: Among the 440 gastroenteritis cases, those who were influenza test-positive were older [median age 4.0 (IQR: 2.3, 5.5) vs. 1.5 (IQR: 0.5, 4.0) years; P = 0.008], more likely to present in fall or winter (92.3 % vs. 48.0 %; P = 0.001), be febrile (84.6 % vs. 30.6 %; P < 0.001), have respiratory symptoms (91.7 % vs. 44.8 %; P = 0.002), have dehydration [median Clinical Dehydration Scale score: 4 (IQR: 1.5, 4.5) vs. 2 (IQR: 0, 3); P = 0.034], and have higher Modified Vesikari Scale scores [median: 13 (IQR: 10.5, 14.0) vs. 10 (IQR: 9.0, 13.0); P = 0.044], than those who tested negative. Thirteen gastroenteritis cases (13/440; 3.0 %) including one child without respiratory symptoms vs. one control (1/250; 0.4 %) were influenza stool positive. Conclusions: Fever, respiratory symptoms, more severe illness, and older age were more common in children with gastroenteritis with influenza detected in stool, compared to those tested negative
Bibliographical noteFunding Information:
This research was supported by APPETITE , which is funded by a grant from the Alberta Innovates–Health Solutions Team Collaborative Research Innovation Opportunity . APPETITE is also supported by the Alberta Children’s Hospital Research Institute (Calgary, AB, Canada) and the Women and Children’s Health Research Institute (Edmonton, AB, Canada) , through a Partnership Award. S.B.F was supported by the Alberta Children’s Hospital Foundation Professorship in Child Health and Wellness . P.I.T was supported by grant number NIH P30DK052574 (Digestive Diseases Research Core Center). G.A.M.T. was supported by a Canadian Institutes of Health Research Banting Postdoctoral Fellowship , Alberta Innovates Health Programs Postgraduate Fellowship , and University of Calgary Eyes High Postdoctoral Fellowship . The Pediatric Emergency Medicine Research Associate Program (PEMRAP) is supported by a grant from the Alberta Children’s Hospital Foundation .
- Reverse transcriptase- quantitative polymerase chain reaction
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't