Influence of therapeutic plasmapheresis on elimination of ceftriaxone

J. S. Bakken, S. J. Cavalieri, D. Gangeness, T. Kubat, J. R. Pollack

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

To study the plasma elimination rate of ceftriaxone given to patients undergoing plasmapheresis, a single 2-g intravenous dose of ceftriaxone was given to 11 patients who underwent plasmapheresis 3 h (early group) or 15 h (late group) later. Even though the early patient group had twofold more ceftriaxone removed than the late group, all individual patients had 24-h ceftriaxone levels of 9 μg/ml or higher. We conclude that patients undergoing plasmapheresis lasting 150 min or less may safely be treated with 2 g of ceftriaxone once daily without risking periods of subtherapeutic plasma ceftriaxone levels.

Original languageEnglish (US)
Pages (from-to)1171-1173
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume37
Issue number5
DOIs
StatePublished - 1993

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