Influence of the Metaboreflex on Pulmonary Vascular Capacitance in Heart Failure

Erik H. Van Iterson, Eric M. Snyder, Bruce D. Johnson, Thomas P. Olson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


PURPOSE: An impaired metaboreflex is associated with abnormal ventilatory and peripheral vascular function in heart failure (HF), whereas its influence on cardiac function or pulmonary vascular pressure remain unclear. We aimed to assess whether metabolite-sensitive neural feedback (metaboreflex) from locomotor muscles via post-exercise regional circulatory occlusion (RCO) attenuates pulmonary vascular capacitance (GXCAP) and/or circulatory power (CircP) in HF patients. METHODS: Eleven HF patients (NYHA class: I/II; ages, 51±15; ejection fraction: 32±9%) and 11 age and gender matched controls (ages, 43±9) completed three cycling sessions (four-minutes, 60% peak oxygen uptake [VO2]). Session one: control trial=normal recovery (NR). Sessions two or three: bilateral upper-thigh pressure tourniquets inflated suprasystolic at end-exercise (RCO) for 2-minute recovery with or without inspired CO2 (RCO+CO2) (randomized). Mean arterial pressure (MAP), heart rate, and VO2 were continuously measured. Estimates of central hemodynamics; CircP=(VO2×MAP)/weight, oxygen pulse index (O2pulseI=(VO2/heart rate)/body surface area), and GXCAP=O2pulseI×end-tidal partial pressure CO2 were calculated. RESULTS: At rest and end-exercise, CircP and GXCAP were lower in HF versus controls (P0.05). At 2-minute recovery, GXCAP was lower during RCO versus NR in both groups (72±23 versus 98±20 and 73±34 versus 114±35 mL[BULLET OPERATOR]beat[BULLET OPERATOR]mm Hg[BULLET OPERATOR]m, respectively; P0.05). Differences (% and Δ) between baseline and 2-minute recovery amongst transients suggest the metaboreflex attenuates GXCAP in HF. Differences (% and Δ) between baseline and 2-min recovery amongst transients suggest the metaboreflex may attenuate CircP in controls. CONCLUSION: The present observations suggest locomotor muscle metaboreflex activation may influence CircP in controls but not in HF. However, metaboreflex activation may evoke decreases in GXCAP (increased pulmonary vascular pressures) in HF and controls.

Original languageEnglish (US)
Pages (from-to)353-362
Number of pages10
JournalMedicine and Science in Sports and Exercise
Issue number3
StatePublished - Mar 1 2016

Bibliographical note

Funding Information:
This work was supported by the American Heart Association grant 12GRNT1160027 (T. P. O.), National Center for Advancing TranslationalScience grant KL2TR000136 (T. P. O.).

Publisher Copyright:
© 2015 by the American College of Sports Medicine.



PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Randomized Controlled Trial


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