Influence of SR Ca2+-ATPase and Na+-Ca 2+-exchanger on the force-frequency relation

W. Schillinger, S. E. Lehnart, J. Prestle, M. Preuss, B. Pieske, L. S. Maier, M. Meyer, H. Just, G. Hasenfuss

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35 Scopus citations


The data presented indicate that altered systolic and diastolic func-tion in failing human hearts may result from altered expression of calcium cycling proteins. Decreased systolic force production and inversion of the force-frequency relation seem to be related to reduced protein levels of SR Ca2+ ATPase and/or to increased protein levels of the Na +-Ca2+ exchanger resulting in an increased ratio of Na+- Ca2+ exchanger to SR Ca2+ ATPase. Impaired diastolic function may result from reduced SR Ca2+ ATPase and is most pronounced in failing hearts with lack of upregulation of the Na +-Ca2+ exchanger. Thus, failing hearts with reduced SR Ca2+ ATPase protein levels and unchanged Na+-Ca 2+ exchanger protein levels exhibit severe impairment of both systolic and diastolic function.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalBasic research in cardiology
Issue number1 SUPPL.
StatePublished - Oct 1998
Externally publishedYes


  • Calcium channel
  • Calcium pump
  • Na-Ca exchanger
  • Ryanodine receptor
  • Sarcoplasmic reticulum


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