Influence of pentobarbital on synaptic plasma membrane protein synthesis

Robert J. Hitzemann, Horace H. Loh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The effects of acute and chronic pentobarbital treatment on the incorporation of 3H-lysine into rat brain synaptic plasma membranes (SPM) were examined by means of SDS polyacrylamide gel electrophoresis. The data suggest the major effects of both drug treatments are found in a unique population of SPM derived from a light population of nerve ending particles (NEP). These light NEP preferentially accumulate labelled GABA, suggesting this fraction is enriched in GABA containing nerve terminals.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalLife Sciences
Issue number1
StatePublished - Jan 1 1977

Bibliographical note

Funding Information:
Male Sprague-Dawley rats (Simonsen Laboratories, Gilroy, CA .) weighing 180-200 g were implanted with a needle guide above the lateral ventricle. Four to 7 days later, the Snimals were implanted with two placebo or two 200 mg ;This study was supported in part by USPHS Grant DA-OOS64. ent of a NINE Research Scientist Career Development Award,


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