This study is aimed at examining the role of nonhemodynamic factors on the impaired microcirculation in patients with moderate essential hypertension. In a series of 31 patients (mean age, 47.8 ± 1.1 years) with newly diagnosed untreated moderate essential hypertension (mean systolic blood pressure 161.7 ± 2.0 mm Hg, mean diastolic blood pressure 102.4 ± 1.5 mm Hg), parameters of the capillaroscopic examination of the finger microcirculation (mean number of capillaries, NRCAP), length of the capillaries (LECAP, /un), diameter /un) of the efferent (EFDI) and afferent (AFDI) apillaries, and mean red blood cell velocity (RBCV, /un/sec), which was measured by the flying spot technique, were correlated with a number of hormones (sampled after an overnight fast) including: plasma renin activity, aldosterone, and parathyroid hormone (PTH). A significant correlation (P <.05) could be obtained between several parameters of the microcirculation and PTH: PTH (23.8 ± 1.4 pg/mL) NRCAP (14.9 ± 0.5): r = 0.440, P = .013; PTH AFDI (4.0 ± 0.5 /un): r = 0.442, P = .012; PTH EFDI (2.8 ± 0.5 /an): r = 0.416, P = .019;PTH RBCV (711 ± 69 /un/sec): r = 0.351, P = .05. Furthermore, 24-h urinary norepinephrine (UNOR) and afferent and efferent diameter of the capillaries intercorrelated significantly: U-NOR (46.0 ± 6.2 /ig/24 h) AFDI: r = 0.439, P = .034; UNOR — EFDI; r = 0.462, P = .025. This study shows that in patients with moderate essential arterial hypertension nonhemodynamic factors have an influence at the level of the microcirculation.
- Essential arterial hypertension
- Parathyroid hormone