Influence of nonhemodynamic factors on the microcirculation in moderate arterial essential hypertension

Daniel Duprez, Marc De Buyzere, Tine De Backer, Jan Vercammen, Jean Marc Kaufman, Marie Van Hoecke, Alex Vermeulen, D. Clement

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4 Scopus citations

Abstract

This study is aimed at examining the role of nonhemodynamic factors on the impaired microcirculation in patients with moderate essential hypertension. In a series of 31 patients (mean age, 47.8 ± 1.1 years) with newly diagnosed untreated moderate essential hypertension (mean systolic blood pressure 161.7 ± 2.0 mm Hg, mean diastolic blood pressure 102.4 ± 1.5 mm Hg), parameters of the capillaroscopic examination of the finger microcirculation (mean number of capillaries, NRCAP), length of the capillaries (LECAP, /un), diameter /un) of the efferent (EFDI) and afferent (AFDI) apillaries, and mean red blood cell velocity (RBCV, /un/sec), which was measured by the flying spot technique, were correlated with a number of hormones (sampled after an overnight fast) including: plasma renin activity, aldosterone, and parathyroid hormone (PTH). A significant correlation (P <.05) could be obtained between several parameters of the microcirculation and PTH: PTH (23.8 ± 1.4 pg/mL) NRCAP (14.9 ± 0.5): r = 0.440, P = .013; PTH AFDI (4.0 ± 0.5 /un): r = 0.442, P = .012; PTH EFDI (2.8 ± 0.5 /an): r = 0.416, P = .019;PTH RBCV (711 ± 69 /un/sec): r = 0.351, P = .05. Furthermore, 24-h urinary norepinephrine (UNOR) and afferent and efferent diameter of the capillaries intercorrelated significantly: U-NOR (46.0 ± 6.2 /ig/24 h) AFDI: r = 0.439, P = .034; UNOR — EFDI; r = 0.462, P = .025. This study shows that in patients with moderate essential arterial hypertension nonhemodynamic factors have an influence at the level of the microcirculation.

Original languageEnglish (US)
Pages (from-to)885-889
Number of pages5
JournalAmerican Journal of Hypertension
Volume4
Issue number11
DOIs
StatePublished - Nov 1991

Keywords

  • Capillaries
  • Essential arterial hypertension
  • Microcirculation
  • Parathyroid hormone

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