Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy

Richard Casaburi, Janos Porszasz, Ariel Hecht, Brian Tiep, Richard K. Albert, Nicholas R. Anthonisen, William C. Bailey, John E. Connett, J. Allen Cooper, Gerard J. Criner, Jeffrey Curtis, Mark Dransfield, Stephen C. Lazarus, Barry Make, Fernando J. Martinez, Charlene McEvoy, Dennis E. Niewoehner, John J. Reilly, Paul Scanlon, Steven M. ScharfFrank C. Sciurba, Prescott Woodruff

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43 Scopus citations


Lightweight ambulatory oxygen devices are provided on the assumptions that they enhance compliance and increase activity, but data to support these assumptions are lacking. We studied 22 patients with severe chronic obstructive pulmonary disease receiving long-term oxygen therapy (14 men, average age = 66.9 y, FEV1 = 33.6%pred, PaO2 at rest = 51.7 torr) who were using E-cylinders as their portable oxygen. Subjects were recruited at 5 sites and studied over a 2-week baseline period and for 6 months after randomizing them to either continuing to use 22-lb E-cylinders towed on a cart or to carrying 3.6-lb aluminum cylinders. Utilizing novel electronic devices, ambulatory and stationary oxygen use was monitored continuously over the 2 weeks prior to and the 6 months following randomization. Subjects wore tri-axial accelerometers to monitor physical activity during waking hours for 23 weeks prior to, and at 3 and 6 months after, randomization. Seventeen subjects completed the study. At baseline, subjects used 17.2 hours of stationary and 2.5 hours of ambulatory oxygen daily. At 6 months, ambulatory oxygen use was 1.4 ± 1.0 hrs in those randomized to E-cylinders and 1.9 ± 2.4 hrs in those using lightweight oxygen (P = NS). Activity monitoring revealed low activity levels prior to randomization and no significant increase over time in either group. In this group of severe chronic obstructive pulmonary disease patients, providing lightweight ambulatory oxygen did not increase either oxygen use or activity. Future efforts might focus on strategies to encourage oxygen use and enhance activity in this patient group. This trial is registered at (NCT003257540).

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
Issue number1
StatePublished - Feb 2012

Bibliographical note

Funding Information:
This study was funded by the COPD Clinical Research Network a 10-site network supported by a Cooperative Agreement (1U10 mechanism) from the National Heart, Lung, and Blood Institute; no funds from commercial sources were utilized. At some sites General Clinical Research Centers (GCRC) were utilized; their M01 grants from the National Center for Research Resources are listed. Members of this Network, with their personnel and grant support are: Brigham and Women’s Hospital – J.J. Reilly, Jr. (PI), G. Washko, (Investigator), S. Peterson, C. Mayo (Coordinator), Grant HL074428, GCRC Grant RR02635; Denver Health Medical Center – R.K. Albert (PI), B. Make (Co-PI), C. Welsh (Investigators), M. Gilmartin, C. Verano (Coordinators), Grant HL074409, GCRC Grant RR00051; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center – R. Casaburi (PI), J. Porszasz (Investigator), R.D. Love (Coordinator), Grant HL074407, GCRC Grant RR00425; Temple University – G.J. Criner (PI); W. Chatila, N. Marchetti, V. Kim, G D’Alonzo, S. Krachman, F. Cordova, K. Brennan, N. Patel, J. Mamary (Investigator), C. Grabianowski, N. Krayger, H. Criner (Coordinators), Grant HL074408; University of Alabama at Birmingham – W.C. Bailey, J.A.D. Cooper (Co-PIs), M.T. Dransfield, L.B Gerald, P. O’Reilly (Investigators), S. Tidwell (Coordinator), Grant HL074418; University of California, San Francisco – S.C. Lazarus (PI), H.A. Boushey, P.G. Woodruff (Investigators), R. Sakurai, C. Nguyen (Coordinators), Grant HL074431; University of Maryland, Baltimore – S.M. Scharf (PI), M.Alattar, P. Amelung, M. Cowan,


  • Activity monitoring
  • Adherence
  • Long-term oxygen therapy
  • Tri-axial accelerometer


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