Abstract
Recurrent chromosomal aberrations in solid tumors can reveal the genetic pathways involved in the evolution of a malignancy and in some cases predict biological behavior. However, the role of individual genetic backgrounds in shaping karyotypes of sporadic tumors is unknown. The genetic structure of purebred dog breeds, coupled with their susceptibility to spontaneous cancers, provides a robust model with which to address this question. We tested the hypothesis that there is an association between breed and the distribution of genomic copy number imbalances in naturally occurring canine tumors through assessment of a cohort of Golden Retrievers and Rottweilers diagnosed with spontaneous appendicular osteosarcoma. Our findings reveal significant correlations between breed and tumor karyotypes that are independent of gender, age at diagnosis, and histological classification. These data indicate for the first time that individual genetic backgrounds, as defined by breed in dogs, influence tumor karyotypes in a cancer with extensive genomic instability.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 365-377 |
| Number of pages | 13 |
| Journal | Chromosome Research |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 2009 |
Bibliographical note
Funding Information:Acknowledgements This work was supported by a grant from the American Kennel Club Canine Health Foundation awarded to M.B./J.M. (CHF 2254), and by charitable donations from individuals, the Starlight Fund, and the Kate Koogler Canine Cancer Research Fund. We thank Eric Seiser for assistance with statistical analysis. We thank all the owners, breeders and veterinarians who contributed samples and data to this study.
Keywords
- Canine
- Chromosome
- Comparative genomic hybridization (CGH)
- Microarray
- Osteosarcoma
