Influence of gender on the disposition of cefotaxime and desacetylcefotaxime

David R.P. Guay, Gary R. Matzke, Karen L Heim-Duthoy, Charles E. Halstenson, Paui A. Abraham, William F. Keane

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The pharmacokinetics of cefotaxime and desacetylcefotaxime were evaluated in 11 female and 13 male subjects with end-stage renal disease. Sub­jects received single 1- or 2-g intravenous doses of cefotaxime sodium. Serum, urine, and dialysate concentrations of cefotaxime and desacetylcefotaxime were determined using high performance liquid chromatography. The results indicate that gender has no clinically significant influence on the disposition of cefotaxime or its active metabolite desacetylcefotaxime.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalTherapeutic drug monitoring
Volume9
Issue number3
DOIs
StatePublished - Sep 1987

Keywords

  • Cefo­taxime
  • Desacetylcefotaxine
  • End Stage Renal Disease (ESRD)
  • Gender
  • Pharmacokinetics

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