Influence of gender on the disposition of cefotaxime and desacetylcefotaxime

David R.P. Guay; Gary R. Matzke; Karen L Heim-Duthoy; Charles E. Halstenson; Paui A. Abraham; William F. Keane

doi:10.1097/00007691-198709000-00002

Influence of gender on the disposition of cefotaxime and desacetylcefotaxime

David R.P. Guay, Gary R. Matzke, Karen L Heim-Duthoy, Charles E. Halstenson, Paui A. Abraham, William F. Keane

Pharmaceutical Care and Health Systems

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The pharmacokinetics of cefotaxime and desacetylcefotaxime were evaluated in 11 female and 13 male subjects with end-stage renal disease. Subjects received single 1- or 2-g intravenous doses of cefotaxime sodium. Serum, urine, and dialysate concentrations of cefotaxime and desacetylcefotaxime were determined using high performance liquid chromatography. The results indicate that gender has no clinically significant influence on the disposition of cefotaxime or its active metabolite desacetylcefotaxime.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	Therapeutic drug monitoring
Volume	9
Issue number	3
DOIs	https://doi.org/10.1097/00007691-198709000-00002
State	Published - Sep 1987

Keywords

Cefotaxime
Desacetylcefotaxine
End Stage Renal Disease (ESRD)
Gender
Pharmacokinetics

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10.1097/00007691-198709000-00002

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title = "Influence of gender on the disposition of cefotaxime and desacetylcefotaxime",

abstract = "The pharmacokinetics of cefotaxime and desacetylcefotaxime were evaluated in 11 female and 13 male subjects with end-stage renal disease. Subjects received single 1- or 2-g intravenous doses of cefotaxime sodium. Serum, urine, and dialysate concentrations of cefotaxime and desacetylcefotaxime were determined using high performance liquid chromatography. The results indicate that gender has no clinically significant influence on the disposition of cefotaxime or its active metabolite desacetylcefotaxime.",

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AU - Guay, David R.P.

AU - Matzke, Gary R.

AU - Heim-Duthoy, Karen L

AU - Halstenson, Charles E.

AU - Abraham, Paui A.

AU - Keane, William F.

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N2 - The pharmacokinetics of cefotaxime and desacetylcefotaxime were evaluated in 11 female and 13 male subjects with end-stage renal disease. Subjects received single 1- or 2-g intravenous doses of cefotaxime sodium. Serum, urine, and dialysate concentrations of cefotaxime and desacetylcefotaxime were determined using high performance liquid chromatography. The results indicate that gender has no clinically significant influence on the disposition of cefotaxime or its active metabolite desacetylcefotaxime.

AB - The pharmacokinetics of cefotaxime and desacetylcefotaxime were evaluated in 11 female and 13 male subjects with end-stage renal disease. Subjects received single 1- or 2-g intravenous doses of cefotaxime sodium. Serum, urine, and dialysate concentrations of cefotaxime and desacetylcefotaxime were determined using high performance liquid chromatography. The results indicate that gender has no clinically significant influence on the disposition of cefotaxime or its active metabolite desacetylcefotaxime.

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KW - Desacetylcefotaxine

KW - End Stage Renal Disease (ESRD)

KW - Gender

KW - Pharmacokinetics

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Influence of gender on the disposition of cefotaxime and desacetylcefotaxime

Abstract

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