Influence of Disorder on Dissolution

Khushboo Kothari, Raj Suryanarayanan

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

This chapter focuses on some of the approaches to enhance drug solubility, with the ultimate goal of enhancing oral bioavailability of poorly water soluble drugs. In order to estimate the dissolution advantage offered by the amorphous form, the solubility advantage should be first assessed. Solid dispersions are a promising strategy to overcome the physical instability associated with amorphous compounds. Polymer structure, including the nature and number of hydrophilic and hydrophobic functional groups, backbone rigidity, and molecular weight have been found to influence the extent and duration of drug supersaturation. Drug-polymer interaction in solution is one of the mechanisms for facilitating the maintenance of drug supersaturation. For a given drug-polymer system, with an increase in polymer concentration, drug supersaturation in solution can be maintained for a longer duration. The stabilization is attributed to an increase in solution viscosity.

Original languageEnglish (US)
Title of host publicationDisordered Pharmaceutical Materials
PublisherWiley-VCH Verlag
Pages57-84
Number of pages28
ISBN (Electronic)9783527652693
ISBN (Print)9783527331253
DOIs
StatePublished - Apr 1 2016

Keywords

  • Amorphous compounds
  • Drug dissolution
  • Drug solubility
  • Drug supersaturation
  • Drug-polymer interaction
  • Polymer concentration
  • Polymer structure
  • Solid dispersions

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